{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:13:09Z","timestamp":1777479189067,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Disturbances in cytokine networks are believed to be associated with increased risk of adverse pregnancy complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Plasma samples collected from pregnant women with preterm deliveries, high-risk pregnancy complications including postpartum hemorrhage, hypertensive disorders, and multiple gestations, and normal pregnancies were analyzed at different periods throughout gestation and postpartum. Interleukin (IL) 1\u03b2 , IL-6, IL-8, IL-10, tumor necrosis factor \u03b1, and antiprotein Z antibody levels were measured by enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The IL-6 levels in preterm delivery patients were elevated during pregnancy with statistically significant differences observed at 21 to 32 weeks ( P &lt; .01) and 33+ weeks ( P &lt; .001). The IL-10 levels were increased in normal pregnancy at all time points compared to the other patient groups ( P &lt; .05). The TNF-\u03b1 levels were elevated in the high-risk pregnancy group versus normal controls ( P &lt; .001 at &lt;21 weeks and P &lt; .05 at 21-32 weeks).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Analysis of the maternal plasma for elevated IL-6 and reduced IL-10 levels may be of value in the early prediction of pregnancy complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1076029613494467","type":"journal-article","created":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T20:29:20Z","timestamp":1374179360000},"page":"152-158","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Inflammatory and Procoagulant Cytokine Levels During Pregnancy as Predictors of Adverse Obstetrical Complications"],"prefix":"10.1177","volume":"20","author":[{"given":"Shannon","family":"Dibble","sequence":"first","affiliation":[{"name":"Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Andersen","sequence":"additional","affiliation":[{"name":"Clinical Trial Unit, Spine Center Copenhagen, Copenhagen University Hospital, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Rud","family":"Lassen","sequence":"additional","affiliation":[{"name":"Clinical Trial Unit, Spine Center Copenhagen, Copenhagen University Hospital, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Cunanan","sequence":"additional","affiliation":[{"name":"Pathology, Loyola University Chicago, Maywood, IL, 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