{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:26:55Z","timestamp":1792614415576,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T00:00:00Z","timestamp":1383696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Biomarkers of endothelial dysfunction are not recommended for routine laboratory investigation of the outcome prognosis and prediction of the course of sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 60 patients who fulfilled the criteria for diagnosis of sepsis were included in our study. Development of multiorgan dysfunction syndrome (MODS) in the first 48 hours was assessed. Differences between groups of patients with sepsis were assessed by Mann-Whitney U test and by Kruskal-Wallis test. Logistic regression analysis was performed to test the joint effect of different predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Level of thrombomodulin was significantly higher in group of patients with MODS than without MODS ( P = .015). Levels of antithrombin ( P = .026) and protein C ( P = .035) were significantly lower in patients with MODS. Level of thrombomodulin was the strongest predictor in MODS development in first 48 hours ( P = .028).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The level of thrombomodulin not only was able to distinguish the severity of sepsis but also was a significant predictor of MODS development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1076029613508600","type":"journal-article","created":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T20:56:00Z","timestamp":1383857760000},"page":"469-474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Thrombomodulin is a Strong Predictor of Multiorgan Dysfunction Syndrome in Patients With Sepsis"],"prefix":"10.1177","volume":"21","author":[{"given":"Dunja M.","family":"Mihajlovic","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Reanimation, Clinical Center of Vojvodina, Emergency Center, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dajana F.","family":"Lendak","sequence":"additional","affiliation":[{"name":"Medical Faculty, Clinical Center of Vojvodina, Clinic for Infectious Diseases, University of Novi Sad, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana G.","family":"Draskovic","sequence":"additional","affiliation":[{"name":"Medical Faculty, Institute of Child and Adolescent Health Care of Vojvodina, Clinic of Pediatric Surgery, University of Novi Sad, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra S. Novakov","family":"Mikic","sequence":"additional","affiliation":[{"name":"Medical Faculty, Clinical Center of Vojvodina, Clinic of Gynecology and Obstetrics, University of Novi Sad, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorana P.","family":"Mitic","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hemostasis, and Prevention of Thrombosis, Medical Faculty, Clinical Center of Vojvodina, Laboratory Medicine Center, University of Novi Sad, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana N.","family":"Cebovic","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical Faculty, University of Novi Sad, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snezana V.","family":"Brkic","sequence":"additional","affiliation":[{"name":"Medical Faculty, Clinical Center of Vojvodina, Clinic for Infectious Diseases, University of Novi Sad, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,11,6]]},"reference":[{"key":"bibr1-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000261890.41311.E9"},{"key":"bibr2-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1754"},{"key":"bibr3-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1023\/B:THRO.0000014592.27892.11"},{"issue":"4","key":"bibr4-1076029613508600","first-page":"1309","volume":"6","author":"Mihajlovic D","year":"2012","journal-title":"Health Med"},{"key":"bibr5-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2005.07.004"},{"key":"bibr6-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05753.x"},{"key":"bibr7-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107001-00022"},{"issue":"3","key":"bibr8-1076029613508600","first-page":"59","volume":"4","author":"Califano F","year":"2000","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"bibr9-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.10.2024.2024"},{"key":"bibr10-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1186\/cc8872"},{"key":"bibr11-1076029613508600","doi-asserted-by":"crossref","unstructured":"Okamoto T, Tanigami H, Suzuki K, Shimaoka M. Thrombomodulin: a bifunctional modulator of inflammation and coagulation in sepsis. Crit Care Res Pract. 2012;20120:614545. http:\/\/www.hindawi.com\/journals\/ccrp\/2012\/614545\/abs\/. Accessed June 30, 2013.","DOI":"10.1155\/2012\/614545"},{"key":"bibr12-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318258ff30"},{"key":"bibr13-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1186\/cc2816"},{"key":"bibr14-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1186\/cc11145"},{"key":"bibr15-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2769-8"},{"key":"bibr16-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1644"},{"key":"bibr17-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000050454.01978.3B"},{"key":"bibr18-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181cc4824"},{"key":"bibr19-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181d69db7"},{"key":"bibr20-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050632"},{"key":"bibr21-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200301000-00002"},{"key":"bibr22-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000245302.18010.40"},{"key":"bibr23-1076029613508600","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2011.587893"},{"key":"bibr24-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01267.x"},{"key":"bibr25-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04319.x"},{"key":"bibr26-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819def97"},{"key":"bibr27-1076029613508600","doi-asserted-by":"publisher","DOI":"10.4266\/kjccm.2008.23.2.90"},{"key":"bibr28-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0B013E31816537D8"},{"key":"bibr29-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1177\/1076029611432744"},{"key":"bibr30-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1177\/107602960100700102"},{"key":"bibr31-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200205001-00023"},{"key":"bibr32-1076029613508600","doi-asserted-by":"publisher","DOI":"10.1186\/1477-9560-11-3"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029613508600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1076029613508600","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029613508600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:05:14Z","timestamp":1777385114000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1076029613508600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,6]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1177\/1076029613508600"],"URL":"https:\/\/doi.org\/10.1177\/1076029613508600","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,6]]}}}