{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:51:47Z","timestamp":1777600307909,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T00:00:00Z","timestamp":1398729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of this open, observational registry was to evaluate the effects of antithrombotic treatment on the development of postthrombotic syndrome (PTS): the effects of \u201cstandard management\u201d (SM; according to International Union of Angiology guidelines) were compared to SM in association with sulodexide or aspirin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Postthrombotic syndrome occurrence was observed in 3 nonparallel groups after deep venous thrombosis (DVT); the registry started after the end of the anticoagulation period. The target was to observe the occurrence of PTS in 5 years. Three possible options were suggested to the patients, and the patients and their caregivers defined the type of management. A group of 167 patients was involved in the SM with reevaluation every 6 months; the sulodexide group included 124 patients and the aspirin group included 48 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The 3 groups were clinically similar and comparable for age and sex distribution. Of the 167 patients in the SM group, 154 patients completed 60 months of follow-up. The percentage of patients with PTS in the SM group ranged from 14.9% (1 year after the end of anticoagulation) to 19.5% (60 months). In the nonparallel group using sulodexide (124 comparable patients at inclusion; 115 at 60 months), the percentage of PTS was variable from 8.8% (1 year after anticoagulants) to 12.17% at 60 months. These percentages are significantly lower than those observed with SM. In the nonparallel aspirin group (48 patients at inclusion and 34 at 54 months), there was a PTS incidence of 23.5% at 54 months (vs 12.17% in the sulodexide group and 18.23% in the SM group). The incidence of PTS was significantly higher in comparison with the other 2 groups. The incidence of PTS was lower in the sulodexide group in comparison with the 2 other groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Sulodexide administration after DVT appears to be effective in preventing PTS in association with recommended management and a number of recurrent DVTs. Modalities of treatment, dosages, and timing of administration should be explored in more comprehensive and complete studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1076029614533143","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T01:03:47Z","timestamp":1398819827000},"page":"594-599","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["The Efficacy of Sulodexide in the Prevention of Postthrombotic Syndrome"],"prefix":"10.1177","volume":"20","author":[{"given":"Roberta","family":"Luzzi","sequence":"first","affiliation":[{"name":"Department of Biomed Sciences, Irvine3 Labs, Circulation Sciences, Chieti-Pescara University, Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Belcaro","sequence":"additional","affiliation":[{"name":"Department of Biomed Sciences, Irvine3 Labs, Circulation Sciences, Chieti-Pescara University, Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Dugall","sequence":"additional","affiliation":[{"name":"Department of Biomed Sciences, Irvine3 Labs, Circulation Sciences, Chieti-Pescara University, Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biomed Sciences, Irvine3 Labs, Circulation Sciences, Chieti-Pescara University, Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Arpaia","sequence":"additional","affiliation":[{"name":"Department of Biomed Sciences, Irvine3 Labs, Circulation Sciences, Chieti-Pescara University, Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ledda","sequence":"additional","affiliation":[{"name":"Department of Biomed Sciences, Irvine3 Labs, Circulation Sciences, Chieti-Pescara University, Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmondo","family":"Ippolito","sequence":"additional","affiliation":[{"name":"Department of Biomed Sciences, Irvine3 Labs, Circulation Sciences, Chieti-Pescara University, Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Corsi","sequence":"additional","affiliation":[{"name":"Department of Biomed Sciences, Irvine3 Labs, Circulation Sciences, Chieti-Pescara University, Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Biomed Sciences, Irvine3 Labs, Circulation Sciences, Chieti-Pescara University, Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Cotellese","sequence":"additional","affiliation":[{"name":"Department of Biomed Sciences, Irvine3 Labs, Circulation Sciences, Chieti-Pescara University, Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Agus","sequence":"additional","affiliation":[{"name":"Department of Biomed Sciences, Irvine3 Labs, Circulation Sciences, Chieti-Pescara University, Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno M.","family":"Errichi","sequence":"additional","affiliation":[{"name":"Department of Biomed Sciences, Irvine3 Labs, Circulation Sciences, Chieti-Pescara University, Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Cornelli","sequence":"additional","affiliation":[{"name":"Department of Biomed Sciences, Irvine3 Labs, Circulation Sciences, Chieti-Pescara University, Chieti and Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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