{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:16:34Z","timestamp":1777479394580,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T00:00:00Z","timestamp":1421625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Abnormal cellular adhesion is one of the primary causes of vaso-occlusive crisis in sickle cell disease (SCD). Levels of intercellular adhesion molecule 1 (ICAM-1) and P-selectin are upregulated, resulting in increased adhesion of leukocytes and sickle red blood cells (RBCs) to endothelium. This study compares the inhibitory effect of a sulfated nonanticoagulant heparin (S-NACH) derivative with a low-molecular-weight heparin, tinzaparin, on the adhesion of sickle RBCs to endothelium. The S-NACH exhibits minimum effects on hemostasis and bleeding and interferes with the binding of pancreatic cancer cells to endothelial cells via P-selectin. We show by static binding assay that pretreatment of both erythrocytes and endothelial cells with S-NACH significantly inhibits the increased adhesion of sickle RBCs to endothelial cells. The S-NACH treatment also decreases the higher plasma levels of (adhesion biomarkers) ICAM-1 and P-selectin in SCD mice. This investigation signals further research into the potential use of S-NACH in treating vaso-occlusions with minimal bleeding events in patients with SCD.<\/jats:p>","DOI":"10.1177\/1076029614565880","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T22:36:38Z","timestamp":1421706998000},"page":"230-238","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Modulation of Sickle Red Blood Cell Adhesion and its Associated Changes in Biomarkers by Sulfated Nonanticoagulant Heparin Derivative"],"prefix":"10.1177","volume":"22","author":[{"given":"Abdulelah","family":"Alshaiban","sequence":"first","affiliation":[{"name":"The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandhana","family":"Muralidharan-Chari","sequence":"additional","affiliation":[{"name":"The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Nepo","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology, Albany Medical College, Albany, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaker A.","family":"Mousa","sequence":"additional","affiliation":[{"name":"The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,1,19]]},"reference":[{"key":"bibr1-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904013401307"},{"key":"bibr2-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1080\/15265161.2013.767964"},{"key":"bibr3-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2007.CDC4"},{"key":"bibr4-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2007.1.91"},{"key":"bibr5-1076029614565880","first-page":"145","volume":"55","author":"Hebbel RP","year":"1981","journal-title":"Prog Clin Biol Res"},{"key":"bibr6-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118355"},{"key":"bibr7-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.07.011"},{"key":"bibr8-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0626"},{"key":"bibr9-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1177\/1076029611420992"},{"key":"bibr10-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-803-4_13"},{"key":"bibr11-1076029614565880","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp090229"},{"key":"bibr12-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(98)00085-4"},{"key":"bibr13-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1509"},{"issue":"9","key":"bibr14-1076029614565880","first-page":"574","volume":"66","author":"Chaplin H","year":"1989","journal-title":"East Afr Med J"},{"key":"bibr15-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2291"},{"issue":"3","key":"bibr16-1076029614565880","first-page":"5","volume":"25","author":"Linhardt RJ","year":"1999","journal-title":"Semin Thromb Hemost"},{"key":"bibr17-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-08-0500"},{"key":"bibr18-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1177\/1076029609352661"},{"key":"bibr19-1076029614565880","doi-asserted-by":"publisher","DOI":"10.1160\/Th06-12-0718"},{"key":"bibr20-1076029614565880","first-page":"CD010155","volume":"6","author":"van Zuuren EJ","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"bibr21-1076029614565880","first-page":"816","volume":"96","author":"Mousa SA","year":"2006","journal-title":"Thromb Haemost"},{"key":"bibr22-1076029614565880","unstructured":"Mousa SA, inventor. 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