{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:17:51Z","timestamp":1777479471353,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T00:00:00Z","timestamp":1432684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The patent protection of low-molecular-weight heparins (LMWHs) expired, so the definition of criteria for the biological similarity between LMWH copies and the original product is a real need.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The present in vitro study compared copies and branded enoxaparin using the specific anti-Xa activity and the calibrated automated thrombogram assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Samples of platelet-poor plasma (PPP) and platelet-rich plasma (PRP) from 15 healthy volunteers were spiked with branded enoxaparin (Lovenox) or its copies (Cutenox, Dilutol, Enoxa, Fibrinox, Loparin, Lupenox, Novex, Noxprin, and Versa). The specific anti-Xa activity was measured in PPP, and thrombin generation was assessed in PPP and PRP in the presence of tissue factor or pancreatic cancer cells BXPC3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The anti-Xa activity of enoxaparin copies ranged from 0.072 to 0.088 IU\/\u03bcg, being lower as compared to the branded enoxaparin (0.095 anti-Xa IU\/\u03bcg). The potency of each copy to inhibit thrombin generation varied in the 3 experimental systems. The presence of platelets or pancreatic cancer cells BXPC3 in human plasma induced significant modifications in the inhibitory efficiency of enoxaparin copies on thrombin generation, which distinguished them from the branded product.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Enoxaparin copies showed significant variability regarding their inhibitory potency on thrombin generation. Platelets and cancer cells significantly increased the variability of the antithrombotic efficiency of the copies as compared to the branded enoxaparin. The present study underlines the need for the elaboration of additional functional criteria to evaluate the global antithrombotic capacity of enoxaparin copies in order to evaluate their potential sameness with the branded drug.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1076029615587355","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T20:00:32Z","timestamp":1432843232000},"page":"697-704","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterization of the Antithrombotic Fingerprint of the Branded and Copies of the Low-Molecular-Weight Enoxaparin Using Thrombin Generation Assay"],"prefix":"10.1177","volume":"21","author":[{"given":"Grigoris T.","family":"Gerotziafas","sequence":"first","affiliation":[{"name":"Service d\u2019H\u00e9matologie Biologique H\u00f4pital Tenon, H\u00f4pitaux Universitaires Est Parisien, Assistance Publique H\u00f4pitaux de Paris, France"},{"name":"INSERM U938, Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, Universit\u00e9 Paris VI, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e8lie","family":"Rouseau","sequence":"additional","affiliation":[{"name":"INSERM U938, Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, Universit\u00e9 Paris VI, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Mbemba","sequence":"additional","affiliation":[{"name":"INSERM U938, Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, Universit\u00e9 Paris VI, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Khartechi","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie Biologique H\u00f4pital Tenon, H\u00f4pitaux Universitaires Est Parisien, Assistance Publique H\u00f4pitaux de Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Van Dreden","sequence":"additional","affiliation":[{"name":"Research and Development, Diagnostica Stago, Gennevilliers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"Walenga","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute Loyola University Chicago, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jawed","family":"Fareed","sequence":"additional","affiliation":[{"name":"Department of Pathology, Loyola University Chicago, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Elalamy","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie Biologique H\u00f4pital Tenon, H\u00f4pitaux Universitaires Est Parisien, Assistance Publique H\u00f4pitaux de Paris, France"},{"name":"INSERM U938, Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, Universit\u00e9 Paris VI, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,5,27]]},"reference":[{"key":"bibr1-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25714"},{"key":"bibr2-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1273089"},{"issue":"6","key":"bibr3-1076029615587355","first-page":"CD006649","author":"Akl EA","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr4-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1016\/B978-008044859-6\/50021-6"},{"key":"bibr5-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9498"},{"key":"bibr6-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02477.x"},{"issue":"2","key":"bibr7-1076029615587355","first-page":"105","volume":"24","author":"Samama MM","year":"1994","journal-title":"Haemostasis"},{"key":"bibr8-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9497"},{"key":"bibr9-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2318(01)57017-1"},{"key":"bibr10-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-23056-1_7"},{"key":"bibr11-1076029615587355","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342120-00003"},{"key":"bibr12-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-06-0409"},{"key":"bibr13-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1066026"},{"issue":"1","key":"bibr14-1076029615587355","first-page":"10","volume":"8","author":"Jeske WP","year":"2008","journal-title":"Acta Colombiana de Cuidado Intensivo"},{"issue":"6","key":"bibr15-1076029615587355","first-page":"517","volume":"31","author":"Walenga JM","year":"2012","journal-title":"Int Angiol"},{"key":"bibr16-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1177\/1076029611426870"},{"key":"bibr17-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008322911"},{"key":"bibr18-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1177\/1076029609338044"},{"key":"bibr19-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-09-0664"},{"key":"bibr20-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1186\/1477-9560-3-16"},{"key":"bibr21-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1661594"},{"key":"bibr22-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.07.049"},{"key":"bibr23-1076029615587355","unstructured":"US Food and Drug Administration. Response to citizen petition, Docket No. FDA-2003-P-0273. Web site. http:\/\/www.regulations.gov. 2010."},{"key":"bibr24-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1648493"},{"issue":"3","key":"bibr25-1076029615587355","first-page":"391","volume":"41","author":"Capila I","year":"2002","journal-title":"Angewandte Chemie"},{"key":"bibr26-1076029615587355","unstructured":"Pharmacopeia, US 35\u2013NF30. Official monographs: enoxaparin sodium. Web site. http:\/\/www.uspnf.com\/uspnf. Accessed December 15, 2012."},{"key":"bibr27-1076029615587355","doi-asserted-by":"publisher","DOI":"10.2174\/157016111206141210121441"},{"key":"bibr28-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v7.i3.40"},{"key":"bibr29-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.07.024"},{"key":"bibr30-1076029615587355","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2400"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029615587355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1076029615587355","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029615587355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:05:47Z","timestamp":1777385147000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1076029615587355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,27]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1177\/1076029615587355"],"URL":"https:\/\/doi.org\/10.1177\/1076029615587355","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,27]]}}}