{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:18:54Z","timestamp":1777479534193,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T00:00:00Z","timestamp":1468108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>We aimed to examine the cross-sectional associations of plasma total homocysteine (tHcy) concentrations and methylenetetrahydrofolate reductase ( MTHFR) C677T genotype with dyslipidemia. A total of 231 patients with mild-to-moderate essential hypertension were enrolled from the Huoqiu and Yuexi communities in Anhui Province, China. Plasma tHcy levels were measured by high-performance liquid chromatography. Genotyping was performed by TaqMan allelic discrimination technique. Compared with MTHFR 677 CC + CT genotype carriers, TT genotype carriers had higher odds of hypercholesterolemia (adjusted odds ratio [OR] [95% confidence interval (CI)]: 2.7 [1.4-5.2]; P = .004) and higher odds of abnormal low-density lipoprotein cholesterol (adjusted OR [95% CI]: 2.3 [1.1-4.8]; P = .030). The individuals with the TT genotype had higher concentrations of log(tHcy) than those with the 677 CC + CT genotype (adjusted \u03b2 [standard error]: .2 [0.03]; P &lt; .001). Patients with tHcy \u2265 10 \u03bcmol\/L had significantly higher odds of hypercholesterolemia (adjusted OR [95% CI]: 2.4 [1.2-4.7]; P = .010). Furthermore, patients with both the TT genotype and the tHcy \u2265 10 \u03bcmol\/L had the highest odds of hypercholesterolemia (adjusted OR [95% CI]: 4.1 [1.8-9.4]; P = .001) and low-density lipoprotein cholesterol (adjusted OR [95% CI]: 2.4 [1.0-6.0]; P = .064). This study suggests that both tHcy and the MTHFR C677T gene polymorphism may be important determinants of the incidence of dyslipidemia in Chinese patients with essential hypertension. Further studies are needed to confirm the role of tHcy and the MTHFR C677T mutation in the development of dyslipidemia in a larger sample.<\/jats:p>","DOI":"10.1177\/1076029615609686","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T20:28:45Z","timestamp":1444163325000},"page":"287-293","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Individual and Joint Associations of Methylenetetrahydrofolate Reductase C677T Genotype and Plasma Homocysteine With Dyslipidemia in a Chinese Population With Hypertension"],"prefix":"10.1177","volume":"23","author":[{"given":"Yanhong","family":"Liu","sequence":"first","affiliation":[{"name":"School of Life Sciences, Anhui University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Anhui University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Venners","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Hsiang","family":"Hsu","sequence":"additional","affiliation":[{"name":"HSL, Institute for Aging Research, Harvard Medical School, Boston, MA, USA"},{"name":"Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanqun","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Anhui University, Hefei, China"},{"name":"Institute of Biomedicine, Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Weinstock","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Virginia, Charlottesville, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genfu","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiping","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Anhui Medical University, Hefei, China"},{"name":"Division of Epidemiology and Biostatistics, University of Illinois at Chicago School of Public Health, Chicago, IL, 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