{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:06:26Z","timestamp":1789391186846,"version":"build-2803163510"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>There are conflicting reports about the protective effect of hemophilia on the occurrence of ischemic heart disease. This study focuses on evaluation of heart function in patients with hemophilia. Cross-sectional, case\u2013control study was done on all patients with hemophilia A or B who came to hemophilia center, and data were compared to controls. The data were collected from their charts, and heart function was evaluated by 2-dimensional, Doppler and pulse tissue Doppler. The serum troponin I level was measured in all patients as a marker of myocardial damage. Fifty patients with hemophilia took part in this study. All of them were male with mean age 29.1 years. Systolic blood pressure (mean = 121.52 \u00b1 11 vs 115.61 \u00b1 9.81, P = .038) and diastolic (mean = 81.94 \u00b1 4.51 vs 75.21 \u00b1 3.95, P = .042) blood pressure were higher in the patients. Five (10%) patients had systolic hypertension and 7 (14%) patients had diastolic hypertension. The M-mode echocardiography results showed that interventricular septum in diastole in patients with hemophilia (mean 1.143 \u00b1 0.29) was significantly thicker than the control group (mean 0.828 \u00b1 0.22, P &lt; .001). Tissue Doppler echocardiography showed that late diastolic velocity of septum (Aa; P = .030), systolic velocity (S) of lateral mitral valve ( P = .006), late diastolic velocity of lateral mitral (Aa) annulus ( P = .038), and late velocity of (Aa) tricuspid ( P = .004) had significant difference compared with the control group ( P &lt; .05). Troponin enzyme level was &lt; 0.1 in all patients. Patients with hemophilia had higher blood pressure and more hypertension. Echocardiographic study of patients with hemophilia showed some increase in septal thickness and changes in diastolic dysfunction<\/jats:p>","DOI":"10.1177\/1076029615614394","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T21:35:00Z","timestamp":1446672900000},"page":"374-378","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of Heart Function in Patients With Hemophilia"],"prefix":"10.1177","volume":"23","author":[{"given":"Hamid","family":"Amoozgar","sequence":"first","affiliation":[{"name":"Cardiac and Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maedeh","family":"Fath","sequence":"additional","affiliation":[{"name":"Pediatric Department, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Jooya","sequence":"additional","affiliation":[{"name":"Pediatric Department, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran","family":"Karimi","sequence":"additional","affiliation":[{"name":"Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,11,4]]},"reference":[{"key":"bibr1-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01946.x"},{"issue":"3","key":"bibr2-1076029615614394","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2516.2009.02188.x","volume":"16","author":"Tagliaferri A","year":"2010","journal-title":"Haemophilia"},{"key":"bibr3-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.1050"},{"key":"bibr4-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02020.x"},{"key":"bibr5-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.01987.x"},{"key":"bibr6-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20339"},{"key":"bibr7-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-05-0313"},{"issue":"6","key":"bibr8-1076029615614394","first-page":"731","volume":"30","author":"Rasmus M","year":"2009","journal-title":"Eur Heart J"},{"key":"bibr9-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1007\/s001340100970"},{"key":"bibr10-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq251"},{"key":"bibr11-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01174"},{"key":"bibr12-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2010.1.191"},{"key":"bibr13-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-07-0460"},{"key":"bibr14-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000171995.22284.9a"},{"key":"bibr15-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.238162"},{"key":"bibr16-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb07793.x"},{"key":"bibr17-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2002.00270.x"},{"key":"bibr18-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00477-6"},{"key":"bibr19-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02608-6"},{"key":"bibr20-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2006.00192.x"},{"key":"bibr21-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.023"},{"key":"bibr22-1076029615614394","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00965-7"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029615614394","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1076029615614394","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029615614394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:05:57Z","timestamp":1777385157000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/1076029615614394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1177\/1076029615614394"],"URL":"https:\/\/doi.org\/10.1177\/1076029615614394","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,4]]}}}