{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:37:30Z","timestamp":1782776250923,"version":"3.54.5"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Many risk factors may contribute to renal disease in patients with hemophilia A.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      We aimed to evaluate functional and structural renal abnormalities among a group of Egyptian children with severe and moderate hemophilia A using technetium-99m diethylene triamine pentaacetic acid (\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-DTPA) and technetium-99 m dimercaptusuccinic acid (\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-DMSA) scan. We also aimed to determine the relation between these abnormalities and different risk factors and disease severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>\n                      Forty male patients, 16 with severe and 24 with moderate hemophilia A, were enrolled in this study. Their mean age was 10.2 \u00b1 4.3 years (range, 5-17 years). Full history taking, clinical examination, laboratory, and radionuclide investigations including serum creatinine, blood urea nitrogen (BUN), urine analysis, creatinine clearance, 24-hour urinary protein,\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-DTPA scan, and\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-DMSA scan were performed to all enrolled patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Serum creatinine and BUN were normal in all patients, and corrected creatinine clearance was diminished in 2 patients. However,\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-DTPA results yielded 19 (47.5%) patients with diminished glomerular filtration rate (GFR). Moreover, it showed that 14 (35%) had obstructive uropathy, 15 (37.5%) had obstructive nephropathy, while 11 (27.5%) patients showed normal scan. One patient had atrophy of 1 kidney on\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-DMSA scan. Among our cohort, 5 (12.5%) patients were hypertensive. Microscopic hematuria was detected in 14 (35%) patients while 72.5% had proteinuria. We found an association between hematuria and hypertension with diminished GFR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Despite normal kidney functions (serum creatinine and BUN), we found a high rate of diminished GFR and obstructive uropathy and nephropathy as detected by\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-DTPA scan among children with hemophilia A.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1076029615619484","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T21:10:34Z","timestamp":1449781834000},"page":"478-486","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Renal Abnormalities Among Egyptian Children With Hemophilia A Using Renal Scintigraphy: Relation to Risk Factors and Disease Severity"],"prefix":"10.1177","volume":"23","author":[{"given":"Ahmed Alsaeed","family":"Hamed","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Hematology Unit, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mennatallah Hatem","family":"Shalaby","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal Saad","family":"El-Kinawy","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa Adel","family":"Elamawy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology Unit, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shereen Mohamed","family":"Abd El-Ghany","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology Unit, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"key":"bibr1-1076029615619484","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2013.06.002"},{"key":"bibr2-1076029615619484","doi-asserted-by":"publisher","DOI":"10.1046\/j.1351-8216.2003.00821.x"},{"key":"bibr4-1076029615619484","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6355.1609"},{"key":"bibr5-1076029615619484","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.3.750"},{"key":"bibr6-1076029615619484","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70175-6"},{"key":"bibr7-1076029615619484","first-page":"168","volume-title":"Nuclear Medicine: The Requisites","author":"Zeissman 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