{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:17:25Z","timestamp":1790291845846,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:00:00Z","timestamp":1455235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The goal of this study was to determine the levels of factor VII (FVII), factor VIIa\u2013antithrombin complexes (FVIIa-AT), total tissue factor (TF), and tissue factor-bearing microparticles (MPs-TF) in patients with acute ischemic stroke. Further, we sought evidence of an association between hemostatic markers, time of blood sampling, type of treatment, and patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Venous blood samples were collected from 33 patients on the first day and on the seventh day after stroke diagnosis. Age-matched controls were also included (n = 20). Plasma levels of FVII, FVIIa-AT, total TF, and MPs-TF were measured by enzyme-linked immunosorbent assay. We divided patients into 2 groups: thrombolysis group (n = 13) and nonthrombolysis group (n = 20). Furthermore, evaluation of the National Institutes of Health Stroke Scale and the Barthel Index was performed on the first day and the seventh day.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients with ischemic stroke showed significantly lower plasma FVII, FVIIa-AT, and total TF levels than controls (median, 112.25% vs 132.05%, P = .004; 107.97 pmol\/L vs 154.94 pmol\/L, P &lt; .001; 81.74 pg\/mL vs 105.71 pg\/mL, P &lt; .001, respectively). In contrast, levels of plasma MPs-TF were significantly higher in patients with stroke compared to healthy controls (1.60 pg\/mL vs 0.74 pg\/mL, P &lt; .001). Additionally, the thrombolysis group had lower FVII levels on the seventh day compared to the first day (median, 109.80% vs 115.74%, P = .04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Factor VII, FVIIa-AT, and total TF are decreased, while MPs-TF are elevated in patients with ischemic stroke. We observed a slight but significant effect of alteplase on FVII plasma levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1076029616631424","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T06:19:11Z","timestamp":1455344351000},"page":"351-359","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Assessing Circulating Factor VIIa\u2013Antithrombin Complexes in Acute Ischemic Stroke: A Pilot Study"],"prefix":"10.1177","volume":"23","author":[{"given":"Artur","family":"S\u0142omka","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, Nicolaus Copernicus University in Toru\u0144, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"\u015awito\u0144ska","sequence":"additional","affiliation":[{"name":"Neurology and Stroke Care Unit, Jan Biziel University Hospital \u2116 2, Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W\u0142adys\u0142aw","family":"Sinkiewicz","sequence":"additional","affiliation":[{"name":"Second Chair of Cardiology, Nicolaus Copernicus University in Toru\u0144, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"\u017bekanowska","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Nicolaus Copernicus University in Toru\u0144, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,2,12]]},"reference":[{"key":"bibr1-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001298"},{"key":"bibr2-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000152"},{"key":"bibr3-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.07.017"},{"key":"bibr4-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.07.011"},{"key":"bibr5-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24380"},{"key":"bibr6-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.06.008"},{"key":"bibr7-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12591"},{"key":"bibr8-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01844.x"},{"key":"bibr9-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2013.1.44"},{"key":"bibr10-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-01-551812"},{"key":"bibr11-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.10.2600.2600"},{"key":"bibr12-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.1.121.bloodjournal851121"},{"key":"bibr13-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-08-0606"},{"key":"bibr14-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103505"},{"key":"bibr15-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.10.1407"},{"key":"bibr16-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70017-7"},{"key":"bibr17-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e318284056a"},{"key":"bibr18-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000040"},{"key":"bibr19-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2273011499"},{"key":"bibr20-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.6.1208"},{"key":"bibr21-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.8.1538"},{"key":"bibr22-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.05.020"},{"key":"bibr23-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.02.046"},{"key":"bibr24-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04152.x"},{"key":"bibr25-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-07-0571"},{"key":"bibr26-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.10.3432.410k16_3432_3441"},{"key":"bibr27-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.11.3.540"},{"key":"bibr28-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3283389513"},{"key":"bibr29-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.05.035"},{"key":"bibr30-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199905)61:1<34::AID-AJH7>3.0.CO;2-T"},{"key":"bibr31-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.10.2101"},{"key":"bibr32-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000086466.32421.F4"},{"key":"bibr33-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01911.x"},{"key":"bibr34-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.12.006"},{"key":"bibr35-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.01.002"},{"key":"bibr36-1076029616631424","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0574fje"}],"container-title":["Clinical 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