{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:09:38Z","timestamp":1784545778756,"version":"3.55.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Recurrent spontaneous abortion (RSA) is defined as 3 or more consecutive pregnancy failures. Thrombin-activatable fibrinolysis inhibitor (TAFI) is a plasma zymogen that regulates both fibrinolysis and inflammation. The TAFI 1040C\/T polymorphism could alter the circulating levels of TAFI with a reduced capacity to remove the fibrin clots from the circulation; therefore, it could be considered a molecular risk factor for RSA. The TAFI 1040C\/T polymorphism was studied in 50 patients with RSA by polymerase chain reaction\u2013restriction fragment length polymorphism technique and compared to 50 age- and gender-matched healthy volunteers as a control group to verify its possible association with RSA. In case group, the wild genotype (C\/C) and heterozygous genotype (C\/T) did not reduce the risk of RSA (odds ratio: 0.368 and 0.767, respectively), even when compared to the number of RSA ( P = .71). A higher frequency of C allele in the control group and a higher frequency of T allele in the case group were observed but with no statistical significance. In conclusion, our study revealed that TAFI 1040C\/T could not be considered a molecular predictive factor for RSA in Egyptians.<\/jats:p>","DOI":"10.1177\/1076029617695485","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T01:53:28Z","timestamp":1487814808000},"page":"532-535","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Thrombin-Activatable Fibrinolysis Inhibitor Gene Polymorphism (TAFI1040C\/T) in Women With Recurrent Spontaneous Abortion"],"prefix":"10.1177","volume":"24","author":[{"given":"Nabil","family":"ElDanasori","sequence":"first","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Kasr Al-Ainy Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Abulata","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical 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