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The aim of this article was to study the pharmacological properties and effectiveness of tinzaparin in patients with cancer as well as its potential anticancer properties. A search of PubMed and ScienceDirect databases up to March 2016 was carried out to identify published studies that detect the properties and use of tinzaparin in oncology. Protamine sulfate partially (60% to 65%) neutralized tinzaparin\u2019s anti-Xa activity. No dose adjustment of tinzaparin is needed even in patients with severe renal impairment and Creatinine Clearance \u226520 mL\/min. Tinzaparin demonstrated a statistically significant decline in VTE recurrence at 1 year post the index thromboembolic event. A statistically significant reduction in minor bleeding rates was also described, whereas major bleeding events did not decrease in patients with cancer treated with tinzaparin versus those who received vitamin K antagonists. Tinzaparin treatment in patients suffering from deep vein thrombosis reduced the incidence of postthrombotic syndrome and venous ulcers. Tinzaparin\u2019s ability to prevent both metastatic dissemination of cancer cells and tumor angiogenesis has been delineated in preclinical research. Current data show that tinzaparin is safe and efficacious either for short-term or for long-term treatment of VTE in patients with cancer. Clinical trials are needed in order to examine the utility of tinzaparin in primary prevention of VTE and validate its potential anticancer advantages exhibited in preclinical research.<\/jats:p>","DOI":"10.1177\/1076029617729215","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T22:45:08Z","timestamp":1509489908000},"page":"697-707","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["The Role of Tinzaparin in Oncology"],"prefix":"10.1177","volume":"24","author":[{"given":"Evangelos P.","family":"Dimakakos","sequence":"first","affiliation":[{"name":"Oncology Unit GPP, Sotiria General Hospital Athens School of Medicine, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Vathiotis","sequence":"additional","affiliation":[{"name":"Oncology Unit GPP, Sotiria General Hospital Athens School of Medicine, Athens, 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