{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:23:57Z","timestamp":1777479837546,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n                    The aim of the study was to evaluate selected angiogenic factors in patients with essential thrombocythemia (ET) depending on JAK2V617F, calreticulin gene (CALR) and myeloproliferative leukemia virus oncogene (MPL) mutations. Sixty ET patients and 20 healthy volunteers were enrolled in the study. The following tests were performed: vascular endothelial growth factor- A (VEGF-A), soluble vascular endothelial growth factor receptor-1 (sVEGFR-1),soluble vascular endothelial growth factor receptor-2\u00a0(sVEGFR-2), platelet-derived growth factor( PDGF-BB), and stromal-derived factor-1\u03b1 (SDF-1\u03b1). We observed an increased PDGF-BB level in patients with ET compared to the controls. Patients with CALR mutation had significantly higher concentration of PDGF-BB and lower concentration of SDF-1\u03b1 than patients with JAK2V617F mutation. High concentration of PDGF-BB and low concentration of SDF-1\u03b1 in patients with CALR(+) ET may indicate a contribution of these chemokines in disturbed Ca\n                    <jats:sup>2+<\/jats:sup>\n                    metabolism in platelets.\n                  <\/jats:p>","DOI":"10.1177\/1076029617740222","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T23:13:50Z","timestamp":1517526830000},"page":"1056-1060","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Selected Parameters of Angiogenesis and the\n                    <i>JAK2<\/i>\n                    ,\n                    <i>CALR<\/i>\n                    , and\n                    <i>MPL<\/i>\n                    Mutations in Patients With Essential Thrombocythemia"],"prefix":"10.1177","volume":"24","author":[{"given":"Gra\u017cyna","family":"Gadomska","sequence":"first","affiliation":[{"name":"Department of Hematology and Malignant Diseases of Hematopoietic System, Faculty of Medicine, Nicolaus Copernicus University in Toru\u0144, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicja","family":"Bartoszewska-Kubiak","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Faculty of Medicine, Nicolaus Copernicus University in Toru\u0144, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Boinska","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toru\u0144, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Matiakowska","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Faculty of Medicine, Nicolaus Copernicus University in Toru\u0144, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Zio\u0142kowska","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toru\u0144, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Haus","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Faculty of Medicine, Nicolaus Copernicus University in Toru\u0144, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danuta","family":"Ro\u015b\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toru\u0144, Collegium Medicum in Bydgoszcz, Bydgoszcz, 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