{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:40:05Z","timestamp":1784043605379,"version":"3.55.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"the Ministry of Education, Culture, Sports, Science and Technology of Japan,","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>We explored the relationship between abdominal vein thromboses, including portal vein thrombosis (PVT) and superior mesenteric vein thrombosis (SMVT), and thrombophilia. The frequency of thrombophilia, such as antithrombin (AT), protein C (PC), or protein S (PS) gene mutations, was examined in 21 patients with PVT, 6 patients with SMVT, and 6 patients with both PVT and SMVT. Low levels of AT, PC, or PS were frequently detected in patients with PVT or mesenteric vein thrombosis, and 4 mutations in the PS gene, 3 mutations in the PC gene, and 2 mutations in AT the gene were detected. Protein S Tokushima was detected in 3 of 4 patients with a PS gene mutation and was associated with 2 other PS gene mutations. The onset of PVT or SMVT was almost idiopathic in patients with congenital thrombophilia. Both PVT and SMVT were frequently caused by an AT, a PC, or a PS mutation, and the onset of these thromboses due to thrombophilia was frequently idiopathic.<\/jats:p>","DOI":"10.1177\/1076029618774146","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T01:31:36Z","timestamp":1526002296000},"page":"1117-1121","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Congenital Thrombophilia in Patients With Superior Mesenteric Venous Thrombosis or Portal Vein Thrombosis"],"prefix":"10.1177","volume":"24","author":[{"given":"Ikejiri","family":"Makoto","sequence":"first","affiliation":[{"name":"Central Laboratory, Mie University Graduate School of Medicine, Tsu, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Usui","sequence":"additional","affiliation":[{"name":"Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Mie University Graduate School of Medicine, Tsu, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohshi","family":"Ohishi","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Mie University Graduate School of Medicine, Tsu, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Shindo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie University Graduate School of Medicine, Tsu, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaname","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Central Laboratory, Mie University Graduate School of Medicine, Tsu, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigehisa","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Ise Redcross Hospital, Ise, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Tomimoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie University Graduate School of Medicine, Tsu, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Isaji","sequence":"additional","affiliation":[{"name":"Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,5,10]]},"reference":[{"key":"bibr1-1076029618774146","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i41.7470"},{"key":"bibr2-1076029618774146","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.08.003"},{"key":"bibr3-1076029618774146","volume-title":"Mesenteric Venous Thrombosis. 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