{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:04:15Z","timestamp":1777478655190,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:p>A variety of viral infections are associated with hypercoagulable states and may be linked to the development of deep venous thrombosis and pulmonary embolism. The Zika and Chikungunya viral infections spread through the South and Central American continents, moving to North America in 2016, with severe cases of polyarthralgia, fever, and Guillain-Barr\u00e9 syndrome leading eventually to death. A decreased trend for both infections was reported in the first quarter of 2017. In this article, we report the possible association of venous thromboembolic events associated with Zika infection. After 2 cases of deep venous thrombosis in patients with acute Zika infections, D-dimer levels were measured in 172 consecutive patients who presented to the emergency department of a university hospital in an endemic region of Brazil with either Zika or Chikungunya infections confirmed by polymerase chain reaction tests. D-dimer levels were increased in 19.4% of 31 patients with Zika and in 63.8% of 141 patients with Chikungunya infections. The mechanisms behind this association are yet to be elucidated as well as the potential for venous thromboembolism prevention strategies for in-hospital patients affected by Zika and Chikungunya infections.<\/jats:p>","DOI":"10.1177\/1076029618821184","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T23:27:50Z","timestamp":1548718070000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":43,"title":["Zika and Chikungunya Virus and Risk for Venous Thromboembolism"],"prefix":"10.1177","volume":"25","author":[{"given":"Eduardo","family":"Ramacciotti","sequence":"first","affiliation":[{"name":"Hospital e Maternidade Dr. Christov\u00e3o da Gama, Santo Andr\u00e9, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro B.","family":"Agati","sequence":"additional","affiliation":[{"name":"Hospital e Maternidade Dr. Christov\u00e3o da Gama, Santo Andr\u00e9, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria C. R.","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Hospital e Maternidade Dr. Christov\u00e3o da Gama, Santo Andr\u00e9, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Wolosker","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o C.","family":"Guerra","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roque P.","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sergipe, Aracaj\u00fa, SE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9294-3257","authenticated-orcid":false,"given":"Juliana Cardoso","family":"Alves","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sergipe, Aracaj\u00fa, SE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato D.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Duke University Hospital, Duke Clinical, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas W.","family":"Wakefield","sequence":"additional","affiliation":[{"name":"Michigan Medicine, Cardiovascular Center, University of Michigan, Ann arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Comerota","sequence":"additional","affiliation":[{"name":"Mercy St. Vincent Medical Center, Toledo, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanine","family":"Walenga","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jawed","family":"Fareed","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"bibr1-1076029618821184","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1600297"},{"key":"bibr2-1076029618821184","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1602708"},{"key":"bibr3-1076029618821184","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3048"},{"key":"bibr4-1076029618821184","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1605367"},{"key":"bibr5-1076029618821184","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602412"},{"key":"bibr6-1076029618821184","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1408509"},{"key":"bibr7-1076029618821184","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1605564"},{"key":"bibr8-1076029618821184","doi-asserted-by":"publisher","DOI":"10.1590\/1677-5449.009616"},{"key":"bibr9-1076029618821184","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23354"},{"key":"bibr10-1076029618821184","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2015.08.017"},{"key":"bibr11-1076029618821184","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001585"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029618821184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1076029618821184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029618821184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:03:30Z","timestamp":1777385010000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1076029618821184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":11,"alternative-id":["10.1177\/1076029618821184"],"URL":"https:\/\/doi.org\/10.1177\/1076029618821184","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"article-number":"1076029618821184"}}