{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:05:48Z","timestamp":1777478748543,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81530013"],"award-info":[{"award-number":["81530013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:p>\n                    Dilated cardiomyopathy (DCM) is increasingly indicated as a cause of cardioembolic syndrome, in particular, cardioembolic ischemia stroke. However, the potential risk factors for stroke among DCM patients remain under investigated. DCM patients hospitalized from June 2011 to June 2016 were included. The cases were defined as the group of DCM patients with stroke compared with those without stroke. Clinical characteristic data were collected and compared between the two groups including demographic data, complicated diseases, echocardiography index, and laboratory parameters and estimated glomerular filtration rate (eGFR). A multivariate logistic regression analysis model adjusted by sex and age was used to explore the related risk factors for stroke in DCM patients. A total of 779 hospitalized patients with DCM were included. Of these, 55 (7.1%) had experienced a stroke. Significantly lower eGFR levels (68.03 \u00b1 26.22 vs 79.88 \u00b1 24.25 mL\/min\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    , P = .001) and larger left atrial diameters (45.32 \u00b1 7.79 vs 43.25 \u00b1 7.11 mm, P = .04) were found in the group of patients having DCM with stroke compared to those without stroke. When the eGFR was categorized as eGFR &gt;60, 30&lt;eGFR\u2264 60 and eGFR \u2264 30, there were more patients with 30&lt;eGFR\u2264 60 (30.9% vs 17.7%) and eGFR\u2264 30 (9.1% vs 3.3%) in the ischemic stroke group ( P = 0.003). A multivariate logistic regression analysis model adjusted by sex and age showed that 30 &lt;eGFR\u226460 (odds ratio [OR]: 2.07, 95% confidence interval [CI]: [1.05-4.07], P = .035) and eGFR\u226430 (OR: 4.04, 95% CI: [1.41-11.62], P = .009) were statistically associated with ischemic stroke in patients with DCM. It is concluded that decreased eGFR is significantly associated with an increased risk of ischemic stroke in patients with DCM.\n                  <\/jats:p>","DOI":"10.1177\/1076029619866909","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T08:22:51Z","timestamp":1564734171000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Decreased eGFR Is Associated With Ischemic Stroke in Patients With Dilated Cardiomyopathy"],"prefix":"10.1177","volume":"25","author":[{"given":"Yuqing","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, the second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People\u2019s Republic of China"},{"name":"Department of Cardiovascular Medicine, the third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People\u2019s Republic of China"},{"name":"Nephrology Department, the second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People\u2019s Republic of China"},{"name":"Jiangxi Key Laboratory of Molecular Medicine, Nanchang, Jiangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinzhu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juxiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinmei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-0862","authenticated-orcid":false,"given":"Kui","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People\u2019s Republic of China"},{"name":"Jiangxi Key Laboratory of Molecular Medicine, Nanchang, Jiangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"issue":"1","key":"bibr1-1076029619866909","first-page":"37","volume":"3","author":"Jeon GJ","year":"2012","journal-title":"Cardiol 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