{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:06:57Z","timestamp":1777478817236,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["T35AI125220"],"award-info":[{"award-number":["T35AI125220"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:p>\n                    Chronic kidney disease stage 5 (CKD5) marks the fifth stage of renal failure, frequently causing dysregulation of bone and mineral metabolism. Challenges exist in evaluating and managing chronic kidney disease\u2013mineral bone disorder (CKD-MBD) with the standard panel of biomarkers. Our objective was to profile osteopontin (OPN) in patients with CKD5 on maintenance hemodialysis (CKD5-HD) and elucidate its relationship to phosphorus (P), calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ), alkaline phosphatase (AP), and intact parathyroid hormone (iPTH) to improve understanding of the present model of CKD-MBD. Elevation of plasma OPN was seen in the CKD5-HD cohort (n = 92; median: 240.25 ng\/mL, interquartile range [IQR]: 169.85 ng\/mL) compared to a normal group (n = 49; median: 63.30 ng\/mL, IQR: 19.20 ng\/mL; p &lt; .0001). Spearman correlation tests revealed significant positive correlations of OPN with iPTH ( p &lt; .0001; r = 0.561, 95% confidence interval = 0.397-0.690) and OPN with AP ( p &lt; .0001; r = 0.444, 95% confidence interval = 0.245-0.590) in CKD5-HD patients. Ultimately, OPN may play an integral role in the MBD axis, suggesting that it may be important to actively monitor OPN when managing CKD5-HD.\n                  <\/jats:p>","DOI":"10.1177\/1076029619896621","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T06:59:47Z","timestamp":1577343587000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Osteopontin Levels in Patients With Chronic Kidney Disease Stage 5 on Hemodialysis Directly Correlate With Intact Parathyroid Hormone and Alkaline Phosphatase"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3090-7960","authenticated-orcid":false,"given":"Aleksander","family":"Druck","sequence":"first","affiliation":[{"name":"Stritch School of Medicine, Loyola University of Chicago, Maywood, IL, USA"},{"name":"Hemostasis and Thrombosis Laboratories, Center of Translational Research and Education, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4378-3589","authenticated-orcid":false,"given":"Dimpi","family":"Patel","sequence":"additional","affiliation":[{"name":"Stritch School of Medicine, Loyola University of Chicago, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Loyola University Medical Center, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Hoppensteadt","sequence":"additional","affiliation":[{"name":"Hemostasis and Thrombosis Laboratories, Center of Translational Research and Education, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3465-2499","authenticated-orcid":false,"given":"Jawed","family":"Fareed","sequence":"additional","affiliation":[{"name":"Hemostasis and Thrombosis Laboratories, Center of Translational Research and Education, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,26]]},"reference":[{"key":"bibr1-1076029619896621","unstructured":"United States Renal Data System. 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