{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:32:08Z","timestamp":1781731928819,"version":"3.54.5"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Scientific Foundation of China","award":["81270593"],"award-info":[{"award-number":["81270593"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p>von Willebrand factor (VWF) acts as a bridge between platelets and the subendothelial matrix following vessel damage and plays a vital role in coronary artery disease (CAD). The aim of this study was to investigate the association between VWF and the severity of coronary stenosis quantified by the Gensini score in acute myocardial infarction (AMI), the most dangerous complication of CAD. Plasma VWF antigen (VWF: Ag) and VWF-collagen binding (VWF: CB) in normal controls (n = 123) and in patients with AMI (n = 205) were tested, and then the patients were divided based on Gensini scores. The levels of VWF: Ag and VWF: CB in patients with AMI were significantly higher than those in the control group ( P &lt; .001). Plasma levels of VWF: Ag and VWF: CB were positively correlated with both Gensini score and the number of affected vessels. Both VWF: Ag and VWF: CB were independent factors for coronary stenosis, adjusting confounding factors. Thus, the levels of VWF: Ag and VWF: CB were positively correlated with the severity of coronary stenosis. Screening of VWF at time of AMI may have prognostic value in terms of the severity of coronary stenosis.<\/jats:p>","DOI":"10.1177\/1076029619900552","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T01:31:19Z","timestamp":1579656679000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Elevated Plasma von Willebrand Factor Antigen and Activity Levels Are Associated With the Severity of Coronary Stenosis"],"prefix":"10.1177","volume":"26","author":[{"given":"Bin","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Nanyang Central Hospital, Nanyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weipeng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Nanyang Central Hospital, Nanyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suping","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Nanyang Central Hospital, Nanyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyang","family":"Gou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Nanyang Central Hospital, Nanyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Nanyang Central Hospital, Nanyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Xia","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China"},{"name":"Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changgeng","family":"Ruan","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6960-9370","authenticated-orcid":false,"given":"Yiming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"bibr1-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq030"},{"key":"bibr2-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.3.365"},{"key":"bibr3-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw106"},{"key":"bibr4-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2016_122"},{"key":"bibr5-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12221"},{"key":"bibr6-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-018-0762-z"},{"key":"bibr7-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2016.03.001"},{"key":"bibr8-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.5.1424"},{"key":"bibr9-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12456"},{"issue":"2","key":"bibr10-1076029619900552","first-page":"204","volume":"84","author":"Sakai H","year":"2000","journal-title":"Thromb Haemost"},{"key":"bibr11-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.12.002"},{"key":"bibr12-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12905"},{"key":"bibr13-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.07.046"},{"key":"bibr14-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.02.002"},{"key":"bibr15-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-016-0287-2"},{"key":"bibr16-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.015"},{"key":"bibr17-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2012.01760.x"},{"key":"bibr18-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(83)80105-2"},{"key":"bibr19-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-5-65"},{"key":"bibr20-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-682484"},{"key":"bibr21-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13032"},{"key":"bibr22-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1038\/srep12235"},{"key":"bibr23-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1177\/1474515116686229"},{"key":"bibr24-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-841932"},{"key":"bibr25-1076029619900552","doi-asserted-by":"publisher","DOI":"10.2174\/138161212802481237"},{"key":"bibr26-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-02-769000"},{"issue":"2","key":"bibr27-1076029619900552","first-page":"204","volume":"84","author":"Sakai H","year":"2000","journal-title":"Thromb Haemost"},{"key":"bibr28-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.63"},{"key":"bibr29-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02161.x"},{"key":"bibr30-1076029619900552","doi-asserted-by":"publisher","DOI":"10.4137\/BMI.S24353"},{"key":"bibr31-1076029619900552","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.05.098"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029619900552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1076029619900552","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029619900552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:03:57Z","timestamp":1777385037000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1076029619900552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":31,"alternative-id":["10.1177\/1076029619900552"],"URL":"https:\/\/doi.org\/10.1177\/1076029619900552","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,1]]},"article-number":"1076029619900552"}}