{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:14:45Z","timestamp":1783977285803,"version":"3.55.0"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"crossref","award":["LQ20H040008, LY20H040009"],"award-info":[{"award-number":["LQ20H040008, LY20H040009"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p>The aim of this study was to investigate the d-dimer for prediction of venous thromboembolism (VTE) events in puerperium and to identify other risk factors associated with the occurrence of VTE. This was a prospective observational cohort study, which included 16 127 women who gave birth after 28 weeks of gestation at Women\u2019s Hospital of Zhejiang University, School of Medicine, from January 2016 to December 2016. Data including basic maternal and fetal characteristics, pregnancy complications, and predictive biomarkers within postpartum 24 hours including d-dimer, platelet, and fibrinogen were collected for analyses. In the cohort study, 19 (0.12%) women were identified as VTE, including 1 pulmonary embolism event and 18 deep venous thrombosis events. The receiver operating characteristic curve analysis suggested the best cutoff point for d-dimer level within postpartum 24 hours was 3.695 mg\/L, with a specificity of 75.5% and a sensitivity of 73.7%, and there was no statistical correlation between fibrinogen and VTE, as well as between platelets and VTE. On multivariate analysis, age \u226535 years (odds ratio [OR] = 2.895, 95% confidence interval [CI]: 1.079-7.773), scarred uterus (OR = 3.894, 95% CI: 1.234-12.282), intrauterine infection (OR = 7.214, 95% CI: 1.519-34.262), antiphospholipid syndrome (OR = 199.530, 95% CI: 15.152-2627.529), d-dimer \u22653.70 mg\/L (OR = 7.573, 95% CI: 2.699-21.247), and emergency cesarean delivery (OR = 23.357, 95% CI: 2.819-193.508) were independently associated with VTE in puerperium. We concluded that d-dimer \u22653.70 mg\/L was an independent predictor of VTE during puerperium and d-dimer testing was necessary for perinatal women.<\/jats:p>","DOI":"10.1177\/1076029620901786","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T07:09:25Z","timestamp":1582528165000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["The Predictive Value of\n                    <scp>d<\/scp>\n                    -Dimer Test for Venous Thromboembolism During Puerperium: A Prospective Cohort Study"],"prefix":"10.1177","volume":"26","author":[{"given":"Wen","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Women\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Changxing Maternal and Child Health Hospital, Huzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Women\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Women\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqun","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Women\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Women\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Women\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Women\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9526-2278","authenticated-orcid":false,"given":"Baihui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Women\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0782-4462","authenticated-orcid":false,"given":"Qiong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Women\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,2,24]]},"reference":[{"key":"bibr1-1076029620901786","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.913130"},{"key":"bibr2-1076029620901786","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-10-200511150-00006"},{"key":"bibr3-1076029620901786","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2019.03.004"},{"key":"bibr4-1076029620901786","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.05.021"},{"key":"bibr5-1076029620901786","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.11.008"},{"key":"bibr6-1076029620901786","volume-title":"Reducing the Risk of Venous Thromboembolism During Pregnancy and the Puerperium","author":"Royal College of Obstetricians and 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