{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:08:11Z","timestamp":1777478891653,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p>To evaluate the prognosis after local thrombolysis compared to systemic thrombolysis in high-risk pulmonary embolism. Observational study during 13 years which included 37 patients with high-risk pulmonary embolism treated with local thrombolysis and 36 patients with systemic thrombolysis (streptokinase, 250 000 UI\/30 minutes followed by 100 000 UI\/h). Cardiogenic shock has totally remitted in the group with local thrombolysis ( P = .002). The decrease in pressure gradient between right ventricle and right atrium was comparable in both groups in the acute period (the results being influenced by the higher in-hospital mortality after systemic thrombolysis), but significantly better in the next 24 months follow-up after in situ thrombolysis. Major and minor bleeding did not have significant differences. In hospital, mortality was significantly lower in the group with local thrombolysis ( P = .003), but for the next 24 months follow-up, the survival was comparable in both groups. Local thrombolysis, during the hospitalization, was associated with lower mortality rate comparing with systemic thrombolysis. In the next 24 months follow-up, the evolution of residual pulmonary hypertension was significantly better after in situ thrombolysis.<\/jats:p>","DOI":"10.1177\/1076029620929764","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T14:25:25Z","timestamp":1598019925000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Local Thrombolysis in High-Risk Pulmonary Embolism\u201413 Years Single-Center Experience"],"prefix":"10.1177","volume":"26","author":[{"given":"Liviu","family":"Macovei","sequence":"first","affiliation":[{"name":"\u201cProf. Dr. George I. M. Georgescu\u201d Cardiovascular Diseases Institute Ia\u015fi, Romania"},{"name":"\u201cGrigore T. Popa\u201d University of Medicine and Pharmacy Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razvan Mihai","family":"Presura","sequence":"additional","affiliation":[{"name":"\u201cProf. Dr. George I. M. Georgescu\u201d Cardiovascular Diseases Institute Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0264-7724","authenticated-orcid":false,"given":"Robert","family":"Magopet","sequence":"additional","affiliation":[{"name":"\u201cProf. Dr. George I. M. Georgescu\u201d Cardiovascular Diseases Institute Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0369-5816","authenticated-orcid":false,"given":"Cristina","family":"Prisecariu","sequence":"additional","affiliation":[{"name":"\u201cProf. Dr. George I. M. Georgescu\u201d Cardiovascular Diseases Institute Ia\u015fi, Romania"},{"name":"\u201cGrigore T. 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