{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:08:56Z","timestamp":1777478936841,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2016YFC0900903"],"award-info":[{"award-number":["2016YFC0900903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p>Very late stent thrombosis (VLST) is a rare but serious complication following percutaneous coronary intervention (PCI). S100A8\/A9 plays an important role in thrombosis through modulating the inflammatory response. This observational study aimed to reveal the association between S100A8\/A9 and VLST. Continuous blood samples were collected from patients at both the time of index PCI for acute myocardial infarction (AMI) and the time of PCI for VLST (VLST group) or follow-up coronary angiography (AMI group). In all, 56 patients were selected in each group from a cohort of 8476 patients and other 112 individuals who underwent health checkups (normal control [NC] group) were selected as controls. Serum levels of S100A8\/A9 and high sensitivity C-reactive protein (hs-CRP) were tested and compared. The mean level of S100A8\/A9 was 3754.4 \u00b1 1688.9 ng\/mL during index PCI and increased to 5517.8 \u00b1 2650.9 ng\/mL at the time of VLST; in the AMI group, S100A8\/A9 level was 2434.9 \u00b1 1243.4 ng\/mL during index PCI and decreased to 1568.2 \u00b1 772.1 ng\/mL during follow-up, similar to that detected in the NC group (1618.2 \u00b1 641.4 ng\/mL). Of note, S100A8\/A9 levels showed significant increases during VLST when compared to its own levels during index PCI, which was different from the changes of hs-CRP. Higher serum levels of S100A8\/A9 are associated with the development of VLST.<\/jats:p>","DOI":"10.1177\/1076029620943295","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T07:51:44Z","timestamp":1596181904000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The Association Between S100A8\/A9 and the Development of Very Late Stent Thrombosis in Patients With Acute Myocardial Infarction"],"prefix":"10.1177","volume":"26","author":[{"given":"Xiang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Disease Center, The First Hospital of Jilin University, Jilin University, Jilin, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Hospital of Jilin University, Jilin University, Jilin, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuhang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, The First Hospital of Jilin University, Jilin University, Jilin, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiyuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, The First Hospital of Jilin University, Jilin University, Jilin, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muli","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University, Guangdong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulin","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, The First Hospital of Jilin University, Jilin University, Jilin, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease Center, The First Hospital of Jilin University, Jilin University, Jilin, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"issue":"3","key":"bibr1-1076029620943295","first-page":"e28","volume":"129","author":"Go 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