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Should cases of patent foramen ovale be closed with mechanical devices in patients with cryptogenic stroke? What are the optimal treatments for cerebral vein thrombosis, carotid artery dissection, and antiphospholipid syndrome and are DOACs acceptable treatment for these indications? What is the mechanism underlying large vessel stroke in patients with COVID-19? This is a narrative review. We searched PubMed and Embase and American College of physicians Journal club database for English language articles since 2000 looking mainly at randomized clinical trials, Meta analyses, Cochran reviews as well as some research articles viewed to be cutting edge regarding anticoagulation and cerebrovascular disease. Searches were done entering cerebral vein thrombosis, carotid dissection, anticoagulation therapy and stroke, antiphospholipid antibody and stroke, stroke in young adults, cryptogenic stroke and anticoagulation, patent foramen ovale and cryptogenic stroke, COVID-19 and stroke.<\/jats:p>","DOI":"10.1177\/10760296211002274","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T07:24:47Z","timestamp":1618817087000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Ischemic Stroke in the Young"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5610-0823","authenticated-orcid":false,"given":"Samuel A.","family":"Berkman","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlee S.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Comprehensive Stroke Center Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"bibr1-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000117571.76197.26"},{"key":"bibr2-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.056275"},{"key":"bibr3-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra042354"},{"key":"bibr4-10760296211002274","first-page":"104","volume":"27","author":"Bousser MG","year":"1997","journal-title":"Maj Prob Neurol"},{"key":"bibr5-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03011.x"},{"key":"bibr6-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90607-Q"},{"key":"bibr7-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.3.484"},{"issue":"4","key":"bibr8-10760296211002274","first-page":"CD002005","author":"Stam J","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr9-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2302"},{"key":"bibr10-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3181f7d043"},{"key":"bibr11-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03690.x"},{"key":"bibr12-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.588822"},{"key":"bibr13-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13381"},{"key":"bibr14-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007903"},{"key":"bibr15-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144856"},{"key":"bibr16-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2764"},{"key":"bibr17-10760296211002274","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2019.00150"},{"key":"bibr18-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02106-7"},{"key":"bibr19-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2018.10.015"},{"key":"bibr20-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12901"},{"key":"bibr21-10760296211002274","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12462"},{"key":"bibr22-10760296211002274","unstructured":"Secret. www.clinicaltrials.gov space registration NCT03178864. 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