{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:55:49Z","timestamp":1778878549162,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No.81471589, No. 81273259"],"award-info":[{"award-number":["No.81471589, No. 81273259"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:p>\n                    Eltrombopag is an orally administered, non-peptide, thrombopoietin receptor agonist which initiates thrombopoietin signaling and stimulates the production of normally functioning platelet. We aimed to do a systematic review and meta-analysis of currently available published data to verify whether eltrombopag treatment in patients with chronic immune-mediated thrombocytopenia can prolong survival. We searched for published, randomized, controlled trials in PubMed, Cochrane and Scopus databases using the following search strategy (\u201cEltrombopag\u201d OR \u201cBenzoates\u201d OR \u201cHydrazines\u201d) AND (\u201cIdiopathic Thrombocytopenic Purpura\u201d OR \u201cimmune thrombocytopenia\u201d OR \u201cIdiopathic Thrombocytopenic Purpuras\u201d OR \u201cImmune Thrombocytopenia\u201d OR \u201cAutoimmune Thrombocytopenia\u201d OR \u201cWerlhof\u201d). The pooled relative risk (RR) showed that eltrombopag group has significantly higher overall platelet response than placebo group (MD = 3.42, 95% CI [2.51, 4.65], P &gt; .0001); pooled results were homogenous ( P = .27, I\n                    <jats:sup>2<\/jats:sup>\n                    = 22%). The pooled relative risk showed that eltrombopag group has lower incidence of any bleeding than placebo group (MD = 0.65, 95% CI [0.48, 0.87], P = .003); pooled results were heterogenous ( P = .001, I\n                    <jats:sup>2<\/jats:sup>\n                    = 75%) and the detected heterogeneity was best resolved after excluding Bussel et al ( P = .10). Homogeneous results were still favored eltrombopag group (MD = 0.75, 95% CI [0.60, 0.93], P = .008).\n                  <\/jats:p>","DOI":"10.1177\/10760296211005555","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T04:16:47Z","timestamp":1618892207000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Eltrombopag Effectiveness and Tolerability in Chronic Immune Thrombocytopenia: A Meta-Analysis"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-8251","authenticated-orcid":false,"given":"Hafiz Abdul Waqas","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Hematology, Zhengzhou University People\u2019s Hospital & Henan Provincial People\u2019s Hospital Henan, Zhengzhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Taher","family":"Masoud","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Fayoum University, Fayoum, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Han","sequence":"additional","affiliation":[{"name":"Kanazawa Medical University, Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Adel Sofy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Fayoum University, Fayoum, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Saeed Ahmed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Fayoum University, Fayoum, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Taha","family":"Abdesattart","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Fayoum University, Fayoum, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel Kwateng","family":"Drokow","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhengzhou University People\u2019s Hospital & Henan Provincial People\u2019s Hospital Henan, Zhengzhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhengzhou University People\u2019s Hospital & Henan Provincial People\u2019s Hospital Henan, Zhengzhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"bibr1-10760296211005555","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"bibr2-10760296211005555","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073275"},{"key":"bibr3-10760296211005555","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000966"},{"key":"bibr4-10760296211005555","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60959-2"},{"key":"bibr5-10760296211005555","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3908"},{"key":"bibr6-10760296211005555","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04695.x"},{"key":"bibr7-10760296211005555","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S213931"},{"key":"bibr8-10760296211005555","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200931"},{"key":"bibr9-10760296211005555","doi-asserted-by":"publisher","DOI":"10.1177\/1076029616663849"},{"key":"bibr10-10760296211005555","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"bibr11-10760296211005555","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"bibr12-10760296211005555","unstructured":"The Cochrane Collaboration RoB 2: A revised Cochrane risk-of-bias tool for randomized trials. 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