{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:09:57Z","timestamp":1784545797361,"version":"3.55.0"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Science and Technology Project of Guangzhou Health and Family Planning Commission","award":["20181A010084"],"award-info":[{"award-number":["20181A010084"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:p>The balance between coagulation and fibrinolysis is essential for a successful pregnancy. This study aimed to explore the genetic variant of +1040C\/T in the coding region of thrombin-activatable fibrinolysis inhibitor (TAFI) gene in women with recurrent spontaneous abortion (RSA) and in unrelated healthy controls and to investigate the possible association between TAFI +1040C\/T polymorphism and RSA. Peripheral blood samples were collected from 137 Chinese patients with RSA and 103 unrelated healthy Chinese controls. The TAFI +1040C\/T polymorphism was analyzed using SNaPshot SNP typing after DNA extraction. The frequency of the C allele was lower in RSA patients compared with the controls (0.78 vs 0.84). A subanalysis of the TAFI +1040C\/T polymorphism in the 2 populations of RSA women (groups 2RSA and &gt;2RSA) showed that the +1040CT genotype was significantly higher and the +1040CC genotype was significantly lower than from that found in controls. The allele +1040C was associated with a reduced risk of RSA in both group 2RSA (OR = 0.418, 95%CI, 0.255-0.685) and group &gt;2RSA (OR = 0.473, 95%CI, 0.274-0.819) compared with controls. Our data indicate a protective role for TAFI +1040C allele against RSA, and may be associated with the genetic susceptibility of RSA.<\/jats:p>","DOI":"10.1177\/10760296211029720","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T06:12:30Z","timestamp":1625033550000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Relationship Between Polymorphism of Thrombin-Activatable Fibrinolysis Inhibitor Gene +1040C\/T and a Cohort of Chinese Women With Recurrent Spontaneous Abortion"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3085-5531","authenticated-orcid":false,"given":"Ping","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory, Affiliated Huadu Hospital, Southern Medical University (People\u2019s Hospital of Huadu District), Guangzhou, Guangdong, People\u2019s Republic of 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory, Affiliated Huadu Hospital, Southern Medical University (People\u2019s Hospital of Huadu District), Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory, Affiliated Huadu Hospital, Southern Medical University (People\u2019s Hospital of Huadu District), Guangzhou, Guangdong, People\u2019s Republic of 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