{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:01:41Z","timestamp":1777478501553,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Carotid and vertebral artery dissections are estimated to account for \u223c20% of strokes in patients under 45-years-old. This meta-analysis compared the efficacy and safety of treatment with anticoagulants versus antiplatelet agents to determine the optimal therapy. We searched 4 electronic databases for clinical trials published from January 1, 1980 to August 25, 2021 that included patients who received anticoagulant or antiplatelet therapy for carotid and\/or vertebral artery dissections. The curative effect was judged by recanalization evaluated by imaging. The primary outcomes were all cause death and ischemic stroke; secondary outcomes included hemorrhage and transient ischemic attack (TIA). Patients who received only a single drug treatment were divided into antiplatelet or anticoagulant groups; all received conservative treatment without surgical intervention. For this investigation, we pooled the available studies to conduct a meta-analysis, which included 7 articles with 1126 patients. The curative effect of vascular recanalization was not significantly different between the 2 treatment groups (odds ratio [OR]\u2009=\u20090.913, 95% confidence interval [CI]: 0.611-1.365, P\u2009=\u2009.657); similarly, no significant differences were found regarding the primary outcomes all cause death (OR\u2009=\u20091.747, 95%CI: 0.202-15.079, P\u2009=\u2009.612) and ischemic stroke (OR\u2009=\u20092.289, 95%CI: 0.997-5.254, P\u2009=\u2009.051). Patients treated with anticoagulants were more likely to experience TIA (OR\u2009=\u20090.517, 95%CI: 0.252-1.060, P\u2009=\u2009.072) and hemorrhage (OR\u2009=\u20090.468, 95%CI: 0.210-1.042, P\u2009=\u2009.063), but the differences were not statistically significant. Overall, there were no statistically significant differences between anticoagulant therapy and antiplatelet therapy for the treatment of carotid and vertebral artery dissections.<\/jats:p>","DOI":"10.1177\/10760296211051708","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T13:37:24Z","timestamp":1638279444000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Oral Anticoagulant and Antiplatelet  Therapy for Cervical Artery Dissection: A Meta-Analysis of Clinical Trials"],"prefix":"10.1177","volume":"27","author":[{"given":"Sheng-Lin","family":"Ye","sequence":"first","affiliation":[{"name":"1Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuang","family":"Wang","sequence":"additional","affiliation":[{"name":"1Nanjing Drum Tower Hospital, The 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