{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:37:44Z","timestamp":1784245064464,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Research Foundation of Liuzhou People's Hospital","award":["lryjc201912"],"award-info":[{"award-number":["lryjc201912"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>This study aims to evaluate the association of serum growth differentiation factor 15 (GDF-15) with in-hospital mortality and arrhythmic risks in patients with acute myocardial infarction (AMI). A total of 296 consecutive patients with AMI were enrolled in our hospital from Jan. 2018 to Dec. 2020. Serum GDF-15 levels were measured at baseline. The primary endpoint was in-hospital all-cause mortality, and the secondary endpoint was major adverse cardiac events (MACEs) during hospitalization, defined as a composite of cardiovascular death, heart failure, sustained ventricular arrhythmias (ventricular tachycardia or ventricular fibrillation), and bleeding. During hospitalization, patients with a higher GDF-15 level had significantly higher incidences of in-hospital mortality (7.4% vs 1.4%; P\u2009=\u2009.02) and MACEs (9.5% vs 20.9%, P\u2009&lt;\u2009.01) than those with a lower GDF-15 level. Multivariate logistic regression analysis showed that a higher GDF-15 level was significantly associated with increased risks of in-hospital mortality (OR\u2009=\u20091.92, 95% CI: 1.44-2.50; P\u2009&lt;\u2009.01) and MACEs (OR\u2009=\u20092.19, 95% CI: 1.56-2.77; P\u2009&lt;\u2009.01). In conclusion, GDF-15 was associated with the risks of in-hospital mortality and MACEs, indicating that it should be a prognostic biomarker for patients with AMI.<\/jats:p>","DOI":"10.1177\/10760296211063875","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T07:46:07Z","timestamp":1641800767000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum GDF-15 Predicts In-Hospital Mortality and Arrhythmic Risks in Patients With Acute Myocardial Infarction"],"prefix":"10.1177","volume":"28","author":[{"given":"Qiuping","family":"Mo","sequence":"first","affiliation":[{"name":"Liuzhou People\u2019s Hospital, Liuzhou, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3853-6105","authenticated-orcid":false,"given":"Liuan","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Liuzhou People\u2019s Hospital, 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