{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:12:34Z","timestamp":1793459554516,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Baoding Science and Technology Bureau project","award":["2041ZF100"],"award-info":[{"award-number":["2041ZF100"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the dynamic variation of D-dimer and to evaluate the efficacy and accuracy of D-dimer level in patients with thoracolumbar fractures caused by high-energy injuries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 121 patients with thoracolumbar fractures caused by high-energy injuries were retrospectively identified and included in this study. There were 83 males and 38 females, with an average age of 48.6\u2009\u00b1\u200911.2 years. All patients were treated with either screw fixation surgery or decompression fixation surgery. The D-dimer levels were measured 1 day before surgery and on the first, third, and fifth days after surgery. The dynamic variation of D-dimer and the effects of risk factors on D-dimer levels were analysed. A receiver operating characteristic (ROC) curve analysis was performed and the appropriate D-dimer cut-off level was determined for deep vein thrombosis (DVT) screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Due to a trough on the third day, D-dimer levels grew in an unsustainable manner following surgery (P &lt; 0.001). Patients with the operation time &gt;120\u2005min (P\u2009=\u20090.009) and those with an American Spinal Injury Association (ASIA) score A-C (P &lt; 0.001) had higher D-dimer levels. The area under the curve of D-dimer was the greatest on the third day. Applying stratified cut-off values did not change the sensitivity, specificity and negative predictive value in the group with an operation time &gt;120\u2005min, and ASIA score A-C group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>D-dimer levels elevated with fluctuation in patients with thoracolumbar fractures caused by high-energy injuries after surgery. Both operation time and ASIA score had an impact on D-dimer levels. Regarding DVT diagnoses, the diagnostic value of D-dimer was highest on the third day postoperatively, and stratified cut-off values by these two factors did not show better diagnostic efficacy compared with a collective one.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296211070009","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T10:43:53Z","timestamp":1641293033000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["The Impact of D-Dimer on Postoperative Deep Vein Thrombosis in Patients with Thoracolumbar Fracture Caused by High-Energy Injuries"],"prefix":"10.1177","volume":"28","author":[{"given":"Haiying","family":"Wang","sequence":"first","affiliation":[{"name":"Baoding No 1 Central Hospital, Baoding, 071000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Lv","sequence":"additional","affiliation":[{"name":"Baoding No 1 Central Hospital, Baoding, 071000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Baoding No 1 Central Hospital, Baoding, 071000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Baoding No 1 Central Hospital, Baoding, 071000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"bibr1-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412153312401"},{"key":"bibr2-10760296211070009","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.15.01329"},{"key":"bibr3-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.3116"},{"key":"bibr4-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002205"},{"key":"bibr5-10760296211070009","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102364"},{"key":"bibr6-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1007\/s00113-020-00860-0"},{"key":"bibr7-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2018.05.007"},{"key":"bibr8-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-018-0880-4"},{"key":"bibr9-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.08.145"},{"key":"bibr10-10760296211070009","first-page":"23","volume":"123","author":"Liu FY","year":"2010","journal-title":"Chin Med J"},{"key":"bibr11-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-024247"},{"key":"bibr12-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2014.12.022"},{"key":"bibr13-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.10.005"},{"key":"bibr14-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-021-00275-w"},{"key":"bibr15-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26212"},{"key":"bibr16-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13133"},{"key":"bibr17-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04895.x"},{"key":"bibr18-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13832"},{"key":"bibr19-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1111\/os.12590"},{"key":"bibr20-10760296211070009","doi-asserted-by":"publisher","DOI":"10.21037\/apm-20-1604"},{"key":"bibr21-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1177\/1076029615588784"},{"key":"bibr22-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2006.1.462"},{"key":"bibr23-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13559"},{"key":"bibr24-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1038\/srep11834"},{"issue":"3","key":"bibr25-10760296211070009","first-page":"425","volume":"51","author":"Owings JT","year":"2001","journal-title":"J Trauma"},{"key":"bibr26-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02192-7"},{"key":"bibr27-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-014-0089-0"},{"key":"bibr28-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.12.139"},{"key":"bibr29-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000020954"},{"key":"bibr30-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82147-x"},{"key":"bibr31-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-018-2371-5"},{"key":"bibr32-10760296211070009","doi-asserted-by":"publisher","DOI":"10.1177\/1076029619826317"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296211070009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296211070009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296211070009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:03:12Z","timestamp":1777384992000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296211070009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":32,"alternative-id":["10.1177\/10760296211070009"],"URL":"https:\/\/doi.org\/10.1177\/10760296211070009","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"10760296211070009"}}