{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:07:34Z","timestamp":1790996854657,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Key Technologies R&D program of China","award":["2016YFC1000303"],"award-info":[{"award-number":["2016YFC1000303"]}]},{"name":"the Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine","award":["Grant No. 41"],"award-info":[{"award-number":["Grant No. 41"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyze the association between pre-operational coagulation indicators and the severity of placenta accreta spectrum (PAS), as well as blood loss volume during operation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Hospitalized patients of the obstetric department in a major hospital from 2018 to 2020 who were clinically and\/or pathologically diagnosed with invasive PAS were included. Univariate and multivariate logistic regression and Poisson regression models were used to quantify the association between each of the 6 coagulation indicators and PAS severity (measured by FIGO grade) as well as maternal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety-five patients (46 FIGO grade 2 and 49 FIGO grade 3) were included. Higher PT [adjusted OR (aOR): 5.54; 95% CI, 1.80 to 17.07] and FDP (aOR: 1.19; 95% CI, 1.01\u20131.42) levels were associated with an increased risk of FIGO grade 3 after adjusting for covariates. D-dimer [incidence rate ratio (IRR): 1.19; 95% CI, 1.05 to 1.35)] and FDP (IRR: 1.03; 95% CI, 1.01\u20131.04) levels were significantly associated with higher blood loss volume after adjusting for covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preoperative coagulation indicators, especially PT, D-dimer and FDP, are associated with disease severity and blood loss volume during operation of invasive PAS. The underlying mechanism for the coagulation profile of PAS patients warrants further analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Synopsis<\/jats:title>\n                    <jats:p>Preoperative coagulation indicators, especially PT, D-dimer and FDP, are associated with disease severity and blood loss volume during operation among invasive placenta accreta spectrum patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296211070580","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T05:20:25Z","timestamp":1641532825000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Association Between Pre-delivery Coagulation Indicators and Invasive Placenta Accreta Spectrum"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6037-8297","authenticated-orcid":false,"given":"Zhirong","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China"},{"name":"Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Peking University First Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China"},{"name":"Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiran","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China"},{"name":"Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China"},{"name":"Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China"},{"name":"Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"bibr1-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1709324"},{"key":"bibr2-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0569-1"},{"key":"bibr3-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.01.233"},{"key":"bibr4-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13547"},{"key":"bibr5-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.04.233"},{"key":"bibr6-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.04.026"},{"key":"bibr7-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.05.011"},{"issue":"21","key":"bibr8-10760296211070580","first-page":"00960","volume":"0002","author":"Jauniaux E","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"bibr9-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12406"},{"issue":"6","key":"bibr10-10760296211070580","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/uog.20246","volume":"53","author":"Cali G","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"key":"bibr11-10760296211070580","volume-title":"Econometric Analysis of Cross Section and Panel Data","author":"Wooldridge JM","year":"2010"},{"key":"bibr12-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13349"},{"issue":"69","key":"bibr13-10760296211070580","first-page":"1","author":"Olson JD","year":"2015","journal-title":"Adv Clin Chem"},{"key":"bibr14-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.03.019"},{"key":"bibr15-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.08.004"},{"key":"bibr16-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.09.046"},{"key":"bibr17-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2017.05.021"},{"key":"bibr18-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000392"},{"key":"bibr19-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12826"},{"key":"bibr20-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.03.010"},{"key":"bibr21-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1635582"},{"key":"bibr22-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1242\/dev.163428"},{"key":"bibr23-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309846"},{"key":"bibr24-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14134"},{"key":"bibr25-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.08.019"},{"key":"bibr26-10760296211070580","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12761"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296211070580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296211070580","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296211070580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:03:12Z","timestamp":1777384992000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296211070580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":26,"alternative-id":["10.1177\/10760296211070580"],"URL":"https:\/\/doi.org\/10.1177\/10760296211070580","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"10760296211070580"}}