{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:02:36Z","timestamp":1777478556821,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"BAYER S.A"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The COMPASS trial demonstrated that in patients with peripheral arterial disease, the combination of rivaroxaban and aspirin compared with aspirin reduces the risk of major adverse limb events, but it is not known whether this combination can also improve symptoms in patients with intermittent claudication. The primary objective of this study is to evaluate the effect of the combination on claudication distance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Eighty-eight patients with intermittent claudication will be randomized to receive rivaroxaban 2.5\u2005mg twice daily plus aspirin 100\u2005mg once daily or aspirin 100\u2005mg once daily for 24 weeks. The primary outcome is the change in claudication distance from the baseline to 24 weeks, measured by 6\u2005min walking test and treadmill test. The primary safety outcome is the incidence of major bleeding and clinically relevant non-major bleeding according to the International Society on Thrombosis and Hemostasis criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>The COMPASS CLAUDICATION trial will provide high-quality evidence regarding the effect of the combination of rivaroxaban and aspirin on claudication distance in patients with peripheral arterial disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296211073922","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T06:04:02Z","timestamp":1642572242000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Rivaroxaban with Aspirin Versus Aspirin for Peripheral Arterial Disease and Intermittent Claudication. Rationale and Design of the COMPASS CLAUDICATION Trial"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-1333","authenticated-orcid":false,"given":"Eduardo","family":"Ramacciotti","sequence":"first","affiliation":[{"name":"Science Valley Research Institute, Santo Andr\u00e9, S\u00e3o Paulo, Brazil"},{"name":"Hospital e Maternidade Dr. Christ\u00f3v\u00e3o da Gama, DASA, S\u00e3o Paulo, SP, Brazil"},{"name":"Hemostasis & Thrombosis Research Laboratories at Loyola University Medical Center, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro Barile","family":"Agati","sequence":"additional","affiliation":[{"name":"Science Valley Research Institute, Santo Andr\u00e9, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliano Giova","family":"Volpiani","sequence":"additional","affiliation":[{"name":"Science Valley Research Institute, Santo Andr\u00e9, S\u00e3o Paulo, Brazil"},{"name":"Hospital e Maternidade Dr. Christ\u00f3v\u00e3o da Gama, DASA, S\u00e3o Paulo, SP, Brazil"},{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Falc\u00e3o","family":"Brito","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla Moreira","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Science Valley Research Institute, Santo Andr\u00e9, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria Cristina Resende","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Science Valley Research Institute, Santo Andr\u00e9, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo Storino","family":"Ramacciotti","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia","family":"Paganotti","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6978-2798","authenticated-orcid":false,"given":"Felipe Menegueti","family":"Pereira","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Augusto","family":"Caffaro","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Fioranelli","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio","family":"Krakauer","sequence":"additional","affiliation":[{"name":"Hospital e Maternidade Dr. Christ\u00f3v\u00e3o da Gama, DASA, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heron Rhydan Saad","family":"Rached","sequence":"additional","affiliation":[{"name":"Hospital Leforte Liberdade, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Wolosker","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia S.","family":"Anand","sequence":"additional","affiliation":[{"name":"McMaster University, Hamilton, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Eikelboom","sequence":"additional","affiliation":[{"name":"McMaster University, Hamilton, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Delascio","family":"Lopes","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"bibr1-10760296211073922","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.052"},{"key":"bibr2-10760296211073922","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.11.3026"},{"key":"bibr3-10760296211073922","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303849"},{"key":"bibr4-10760296211073922","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2018.03.038"},{"key":"bibr5-10760296211073922","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.12.007"},{"key":"bibr6-10760296211073922","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709118"},{"key":"bibr7-10760296211073922","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32409-1"},{"key":"bibr8-10760296211073922","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.002"},{"key":"bibr9-10760296211073922","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318276fbcb"},{"key":"bibr10-10760296211073922","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.10.014"},{"key":"bibr11-10760296211073922","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.05.111"},{"key":"bibr12-10760296211073922","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13140"},{"key":"bibr13-10760296211073922","first-page":"CD003748","volume":"10","author":"Bedenis R","year":"2014","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296211073922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296211073922","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296211073922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:03:14Z","timestamp":1777384994000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296211073922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":13,"alternative-id":["10.1177\/10760296211073922"],"URL":"https:\/\/doi.org\/10.1177\/10760296211073922","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"10760296211073922"}}