{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:02:35Z","timestamp":1777478555073,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016387","name":"Grifols","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of a plasma-derived factor VIII concentrate containing von Willebrand Factor (pdVWF\/FVIII) in standard clinical practice in von Willebrand Disease (VWD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective, multicentric, observational study of VWD patients treated with Fanhdi\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , a pdVWF\/FVIII concentrate, from January 2011 to December 2017 was conducted at 14 centers in Spain. Efficacy and safety were evaluated for acute bleeding episodes, for prevention of bleeding in surgeries, and for secondary long-term prophylaxis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy-two eligible patients, type 1, 2, 3 VWD (25%\/38.9%\/36.1%) were treated for spontaneous and traumatic bleeding (140 episodes, n\u2009=\u200941 patients), to prevent surgical bleeding (69 episodes, n\u2009=\u200943 patients); and for secondary long-term prophylaxis (18 programs, n\u2009=\u200913 patients). Replacement therapy with pdVWF\/FVIII showed an excellent to good clinical efficacy in 96.7% of the bleeding episodes, 100% during surgical procedures and 100% during prophylaxis. No adverse events (AEs), nor serious AEs related to the product were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Fanhdi\n                      <jats:sup>\u00ae<\/jats:sup>\n                      was effective, safe and well tolerated in the management of bleeding episodes, the prevention of bleeding during surgeries, and for secondary long-term prophylaxis in VWD patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296221074348","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T12:08:42Z","timestamp":1643803722000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Efficacy and Safety of Fanhdi\n                    <sup>\u00ae<\/sup>\n                    , a Plasma-Derived VWF\/Factor VIII Concentrate, in von Willebrand Disease in Spain: A Retrospective Study"],"prefix":"10.1177","volume":"28","author":[{"given":"V\u00edctor","family":"Jim\u00e9nez-Yuste","sequence":"first","affiliation":[{"name":"Department of Hematology and Hemotherapy, Hospital Universitario La Paz, Aut\u00f3noma University, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Teresa","family":"Alvarez-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hemotherapy, Hospital Universitario La Paz, Aut\u00f3noma University, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngeles","family":"Palomo Bravo","sequence":"additional","affiliation":[{"name":"Hematology Service, Hospital Materno-Infantil de M\u00e1laga, M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo 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Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy Service, Complejo Universitario Torrec\u00e1rdenas, Almer\u00eda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Coll","sequence":"additional","affiliation":[{"name":"Hematology Service, Complejo Hospitalario de Navarra, Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Hematology Service, Hospital Virgen del Roc\u00edo, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Thrombosis and Hemostasis Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faustino","family":"Garc\u00eda Candel","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy Service, Hospital Cl\u00ednico Universitario Virgen Arrixaca, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Ramon","family":"Gonzalez-Porras","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital Universitario de Salamanca-IBSAL-USAL, Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Hern\u00e1ndez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy Service, Hospital de Don Benito-Villanueva, Badajoz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jos\u00e9","family":"Var\u00f3 Castro","sequence":"additional","affiliation":[{"name":"Hematology Service, Hospital Universitario de Albacete, Albacete, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roser","family":"Mir","sequence":"additional","affiliation":[{"name":"Scientific and Medical Affairs Department, Grifols, Barcelona, 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