{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:02:55Z","timestamp":1777478575112,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>COVID-19 is a new form of acute respiratory failure leading to multiorgan failure and ICU admission. Gathered evidence suggests that a 3-fold rise in D-dimer concentrations may be linked to poor prognosis and higher mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe D-dimer admission profile in severe ICU COVID19 patients and its predictive role in outcomes and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single-center retrospective cohort study. All adult patients admitted to ICU with COVID19 were divided into 3 groups: (1) Lower-values group (D-dimer levels &lt; 3-fold normal range value [NRV] [500ng\/mL]), Intermediate-values group (D-dimer \u22653-fold and &lt;10-fold NRV) and Higher-value group (\u226510-fold NRV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>118 patients (mean age 63 years, 73% males) were included (N\u2009=\u200973 Lower-values group, N\u2009=\u200931 Intermediate-values group; N\u2009=\u200911 Higher-values group). Mortality was not different between groups (p\u2009=\u20090.51). Kaplan-Meier survival curves revealed no differences (p\u2009=\u20090.52) between groups, nor it was verified even when gender, age, ICU length of stay, and SOFA score were considered as covariables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In severe COVID19 patients, the D-dimer profile does not retain a predictive value regarding patients\u2019 survivability and should not be used as a surrogate of disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296221079612","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T04:26:22Z","timestamp":1644467182000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Predictive value of D-dimer in the clinical outcome of severe COVID19 patients:  Are we giving it too much credit?"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-5171","authenticated-orcid":false,"given":"Jos\u00e9 P.","family":"Cidade","sequence":"first","affiliation":[{"name":"Polyvalent Intensive Care Unit, S\u00e3o Francisco Xavier Hospital, CHLO, Lisbon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds","family":"Coelho","sequence":"additional","affiliation":[{"name":"Polyvalent Intensive Care Unit, S\u00e3o Francisco Xavier Hospital, CHLO, Lisbon"},{"name":"Nova Medical School, Clinical Medicine, CHRC, New University of Lisbon, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasco","family":"Costa","sequence":"additional","affiliation":[{"name":"Polyvalent Intensive Care Unit, S\u00e3o Francisco Xavier Hospital, CHLO, Lisbon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Morais","sequence":"additional","affiliation":[{"name":"Polyvalent Intensive Care 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Lisbon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Tapadinhas","sequence":"additional","affiliation":[{"name":"Polyvalent Intensive Care Unit, S\u00e3o Francisco Xavier Hospital, CHLO, Lisbon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"P\u00f3voa","sequence":"additional","affiliation":[{"name":"Polyvalent Intensive Care Unit, S\u00e3o Francisco Xavier Hospital, CHLO, Lisbon"},{"name":"Nova Medical School, Clinical Medicine, CHRC, New University of Lisbon, Lisbon, Portugal"},{"name":"Center for Clinical Epidemiology and Research Unit of Clinical Epidemiology, OUH Odense University Hospital, Odense, 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