{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:07:29Z","timestamp":1790996849083,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Clinical Study of Shanghai Municipal Health Commission","award":["No.202040338"],"award-info":[{"award-number":["No.202040338"]}]},{"name":"The National Key Research and Development Program of China: precision medicine and administration of severe infections in children","award":["No.2021YFC2701800"],"award-info":[{"award-number":["No.2021YFC2701800"]}]},{"name":"The National Key Research and Development Program of China: precision medicine and administration of severe infections in children","award":["No.2021YFC2701804"],"award-info":[{"award-number":["No.2021YFC2701804"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigated the clinical efficacy of Soluble thrombomodulin (sTM), tissue plasminogen activator inhibitor complex (t-PAI\u00b7C),thrombin-antithrombin complex (TAT),\u03b12-plasmininhibitor-plasmin complex (PIC) in pediatric sepsis and pediatrics sepsis-induced coagulopathy (pSIC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively collected patient data with sepsis diagnosed in the PICU of Shanghai Children's Medical Center from June 2019 to June 2021. sTM,t-PAI\u00b7C, TAT,PIC and classical coagulation laboratory tests (CCTs) were evaluated on the day of sepsis diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-nine children were enrolled, There were significant differences in t-PAI\u00b7C (P\u2009=\u20090.001), Plt (P &lt; 0.001), PT (P &lt; 0.001), INR (P &lt; 0.001), aPTT (P &lt; 0.001), and TT (P\u2009=\u20090.048) between the pSIC and non-pSIC groups, logistic regression analysis showed that Plt (P\u2009=\u20090.032) was an independent risk factor for pSIC. Logistic regression analysis showed that sTM (P\u2009=\u20090.007) and Plt (P\u2009=\u20090.016) were independent risk factors for the outcome in pediatrics sepsis following discharge. The AUC of sTM combined with Plt on the mortality outcome of children with sepsis at discharge was 0.889 (95%CI: 0.781,0.956). which was better than that for PRISM III (AUC, 0.723), pSOFA (AUC, 0.764), and blood Lac (AUC, 0.717) when sepsis was diagnosed in the PICU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The t-PAI\u00b7C increased in children with pSIC. The prediction of sepsis outcome using sTM combined with Plt was better than with PRISM III, pSOFA, or Lac.Further research is still needed in the future to explore the clinical value of sTM, TAT, PIC, and t-PAI\u00b7C in diagnosis and outcome of pediatrics sepsis and pSIC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296221102929","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T01:09:25Z","timestamp":1653268165000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical Efficacy of Soluble Thrombomodulin, Tissue Plasminogen Activator Inhibitor complex, Thrombin-Antithrombin complex,\u03b12-Plasmininhibitor-Plasmin complex in Pediatric Sepsis"],"prefix":"10.1177","volume":"28","author":[{"given":"Juanzhen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Ren Ji Hostipal, Shanghai Jiao Tong University School of Medicine, Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biru","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0276-9115","authenticated-orcid":false,"given":"Long","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Department of Neonatal, Second People\u2019s Hospital of Kashgar, Xinjiang Uygur Autonomous Region, 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