{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:36:31Z","timestamp":1791304591945,"version":"4.3.1"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Scientific Research Project of Heilongjiang Provincial Health Commission","award":["2019-013"],"award-info":[{"award-number":["2019-013"]}]},{"name":"Scientific Research Project of Heilongjiang Provincial Health Commission","award":["2019-017"],"award-info":[{"award-number":["2019-017"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Podoplanin (PDPN) promotes platelet aggregation and activation by interacting with C-type lectin-like receptor 2(CLEC-2) on platelets. The interaction between the upregulated PDPN and platelet CLEC-2 stimulates venous thrombosis. PDPN was identified as a risk factor for coagulation and thrombosis in inflammatory processes. Hypercoagulability is defined as the tendency to develop thrombosis according to fibrinogen and\/or D dimer levels. Nephrotic syndrome is also considered to be a hypercoagulable state. The aim of this study is to investigate the association of soluble PDPN\/CLEC-2 with hypercoagulability in nephrotic syndrome. Thirty-five patients with nephrotic syndrome and twenty-seven healthy volunteers were enrolled. PDPN, CLEC-2 and GPVI concentrations were tested by enzyme-linked immunosorbent assay (ELISA). Patients with nephrotic syndrome showed higher serum levels of PDPN and GPVI in comparison to healthy controls ( P\u2009&lt;\u2009.001, P\u2009=\u2009.001). PDPN levels in patients with nephrotic syndrome were significantly correlated with GPVI (r\u2009=\u20090.311; P\u2009=\u2009.025), hypoalbuminemia (r\u2009=\u2009\u22120.735; P\u2009&lt;\u2009.001), hypercholesterolemia (r\u2009=\u20090.665; P\u2009&lt;\u2009.001), hypertriglyceridemia (r\u2009=\u20090.618; P\u2009&lt;\u2009.001), fibrinogen (r\u2009=\u20090.606; P\u2009&lt;\u2009.001) and D-dimer (r\u2009=\u20090.524; P\u2009&lt;\u2009.001). Area under the curve (AUC) for the prediction of hypercoagulability in nephrotic syndrome using PDPN was 0.886 (95% CI 0.804-0.967, P\u2009&lt;\u2009.001). Cut-off value for the risk probability was 5.88\u2005ng\/ml. The sensitivity of PDPN in predicting hypercoagulability was 0.806, and the specificity was 0.846. When serum PDPN was &gt;5.88\u2005ng\/ml, the risk of hypercoagulability was significantly increased in nephrotic syndrome (OR\u2009=\u200922.79, 95% CI 5.92-87.69, P\u2009&lt;\u2009.001). In conclusion, soluble PDPN levels were correlated with hypercoagulability in nephrotic syndrome. PDPN has the better predictive value of hypercoagulability in nephrotic syndrome as well as was a reliable indicator of hypercoagulable state.<\/jats:p>","DOI":"10.1177\/10760296221108967","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T12:48:30Z","timestamp":1658407710000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Elevated Soluble Podoplanin Associates with Hypercoagulability in Patients with Nephrotic Syndrome"],"prefix":"10.1177","volume":"28","author":[{"given":"Ying","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Bei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Hong","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Yan","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, First 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