{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:04:25Z","timestamp":1777478665859,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Baxalta US Inc., a Takeda company, Lexington, MA, USA"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Von Willebrand disease (VWD) is one of the most common inherited bleeding disorders, imposing a substantial health impact and financial burden. The Cost of von Willebrand disease in Europe: A Socioeconomic Study (CVESS) characterises the socio-economic cost of VWD across Germany, Spain, Italy, France, and the UK.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective, cross-sectional design captured 12 months of patient disease management, collected from August-December 2018, for 974 patients. This enabled estimation of direct medical, direct non-medical and indirect costs, utilising prevalence estimates to extrapolate to population level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total annual direct medical cost (including\/excluding von Willebrand factor [VWF]) across all countries was the highest cost (\u20ac2\u2005845\u2005510\u2005345\/\u20ac444\u2005446\u2005023), followed by indirect costs (\u20ac367\u2005330\u2005271) and direct non-medical costs (\u20ac60\u2005223\u2005234). Differences were seen between countries: the UK had the highest direct medical costs excluding VWF (\u20ac159\u2005791\u2005064), Italy the highest direct-non medical (\u20ac26\u2005564\u2005496), and Germany the highest indirect cost burden (\u20ac197\u2005036\u2005052). Total direct medical costs per adult patient increased across VWD types with Type 1 having the lowest cost (\u20ac23\u2005287) and Type 3 having the highest cost (\u20ac133\u2005518).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A substantial financial burden arises from the prevalence of VWD for the European healthcare systems considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296221120583","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T02:36:03Z","timestamp":1660790163000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Cost of Von Willebrand Disease in Europe: The CVESS Study"],"prefix":"10.1177","volume":"28","author":[{"given":"George","family":"Morgan","sequence":"first","affiliation":[{"name":"HCD Economics, Daresbury, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-368X","authenticated-orcid":false,"given":"Sarah","family":"Brighton","sequence":"additional","affiliation":[{"name":"HCD Economics, Daresbury, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Laffan","sequence":"additional","affiliation":[{"name":"Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Goudemand","sequence":"additional","affiliation":[{"name":"Department of Hemostasis and Transfusion, Lille University Hospital, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethany","family":"Franks","sequence":"additional","affiliation":[{"name":"HCD Economics, Daresbury, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Finnegan","sequence":"additional","affiliation":[{"name":"Faculty of Health and Social Care, University of Chester, Chester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"issue":"2","key":"bibr1-10760296221120583","first-page":"s45","volume":"6","author":"Peyvandi F","year":"2008","journal-title":"Blood Transfus"},{"key":"bibr2-10760296221120583","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13632"},{"key":"bibr3-10760296221120583","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03661.x"},{"key":"bibr4-10760296221120583","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-528398"},{"key":"bibr5-10760296221120583","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1281028"},{"key":"bibr6-10760296221120583","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-782029"},{"key":"bibr7-10760296221120583","unstructured":"World Federation of Hemophilia. 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