{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:08:02Z","timestamp":1790820482935,"version":"4.1.0"},"reference-count":69,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Lida and Oskar Nielsens Foundation"},{"DOI":"10.13039\/501100008218","name":"Gangstedfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008218","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Research Foundation of Southern Denmark"},{"name":"Esbjerg Foundation"},{"name":"Et Sundere Syddanmark"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Preeclampsia (PE) is a serious complication of pregnancy. The fibrinolytic system play crucial roles regarding placentation and evolution of PE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To study comprehensively components of the fibrinolytic system and fibrin lysability in women with PE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Methods<\/jats:title>\n                    <jats:p>117 women with PE and matched controls were included. Tissue type plasminogen activator (t-PA), plasminogen, PAI-1, plasmin inhibitor (PI), D-dimer, the fibrinolytic potential of dextran sulphate euglobulin fraction (DEF), PAI-2, polymere PAI-2, fibrin clot lysability, thrombin activatable fibrinolysis inhibitor (TAFI) and fibrinogen were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Women with PE had significantly increased concentrations of t-PA and PAI-1, whereas the plasma concentration of PAI-2 was significantly lower compared to controls, p\u2009&lt;\u20090.0001. Polymere PAI-2 was detected in both groups. DEF, TAFI and fibrinogen were not different between the groups. D-dimer was significantly increased and plasminogen\/PI together with fibrin clot lysability time decreased in the PE-group, p\u2009\u2009=\u2009\u20090.0004 p\u2009\u2009=\u2009\u20090.04, p\u2009\u2009=\u2009\u20090.03, p\u2009&lt;\u20090.0001 respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that PE is associated with an affected t-PA\/PAI-1 system, decreased PAI-2 and increased fibrin lysability. Furthermore, PAI-2 has the potential to polymerize during pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296221126172","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T03:01:02Z","timestamp":1665457262000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Fibrinolytic Changes in Women with Preeclampsia"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7043-5315","authenticated-orcid":false,"given":"Anne Cathrine","family":"Godtfredsen","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital of Southern Denmark, Esbjerg, Denmark"},{"name":"Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes Jakobsen","family":"Sidelmann","sequence":"additional","affiliation":[{"name":"Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark"},{"name":"Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta Blume","family":"Dolleris","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Stener","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma Kathrine Jungjohan","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Cancer and Inflammation Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Fernard B\u00f8g","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cancer and Inflammation Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaseelan","family":"Palarasah","sequence":"additional","affiliation":[{"name":"Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark"},{"name":"Department of Cancer and Inflammation Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen Brodersen","family":"Gram","sequence":"additional","affiliation":[{"name":"Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark"},{"name":"Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"bibr1-10760296221126172","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12081115"},{"key":"bibr2-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23693"},{"key":"bibr3-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2022.103490"},{"key":"bibr4-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000233364.72863.a0"},{"key":"bibr5-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996035"},{"key":"bibr6-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1159\/000362666"},{"key":"bibr7-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1003475"},{"key":"bibr8-10760296221126172","unstructured":"Sidelmann J\n                      J\n                      . Contact activation of the fibrinolytic system in human blood. Biochemical and analytical aspects. Ph.D-thesis.\n                      South Jutland University Press\n                      . 1997."},{"key":"bibr9-10760296221126172","doi-asserted-by":"publisher","DOI":"10.3109\/10641950903242675"},{"key":"bibr10-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008808"},{"key":"bibr11-10760296221126172","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.896811"},{"key":"bibr12-10760296221126172","author":"Nielsen LHS","year":"2018","journal-title":"Dansk Selskab for Obstetrik og Gyn\u00e6kologi"},{"key":"bibr13-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.05.004"},{"key":"bibr14-10760296221126172","volume-title":"Collection of Diagnostic Venous Blood Specimens","author":"CLSI","year":"2017","edition":"7"},{"key":"bibr15-10760296221126172","volume-title":"Collection of Diagnostic Blood Speciments for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays","author":"CLSI"},{"key":"bibr16-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-015-3106-z"},{"key":"bibr17-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1159\/000205234"},{"key":"bibr18-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13825"},{"key":"bibr19-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/41.7.979"},{"key":"bibr20-10760296221126172","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.873975"},{"key":"bibr21-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3601-1"},{"key":"bibr22-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1159\/000291899"},{"key":"bibr23-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2012.01.004"},{"key":"bibr24-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03344.x"},{"key":"bibr25-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1159\/000292703"},{"key":"bibr26-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2002.01257.x"},{"key":"bibr27-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.07.035"},{"key":"bibr28-10760296221126172","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v18i3.15"},{"key":"bibr29-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.07.014"},{"key":"bibr30-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.081372"},{"key":"bibr31-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.02.007"},{"key":"bibr32-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1645047"},{"key":"bibr33-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1648415"},{"key":"bibr34-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13147.x"},{"key":"bibr35-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1646429"},{"key":"bibr36-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90113-2"},{"key":"bibr37-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90242-J"},{"issue":"12","key":"bibr38-10760296221126172","first-page":"898","volume":"83","author":"de Jager CA","year":"1993","journal-title":"S Afr Med J"},{"key":"bibr39-10760296221126172","author":"Agersnap I","journal-title":"Semin Thromb Hemost."},{"key":"bibr40-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.09.050"},{"issue":"1","key":"bibr41-10760296221126172","first-page":"39","volume":"61","author":"Prochazka M","year":"2015","journal-title":"Clin Lab"},{"key":"bibr42-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1080\/10641955.2016.1211676"},{"key":"bibr43-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/219350"},{"key":"bibr44-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(96)02755-5"},{"key":"bibr45-10760296221126172","doi-asserted-by":"publisher","DOI":"10.4103\/1119-3077.183256"},{"key":"bibr46-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90016-6"},{"key":"bibr47-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb12982.x"},{"key":"bibr48-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaaa061"},{"key":"bibr49-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199512000-00002"},{"issue":"3","key":"bibr50-10760296221126172","first-page":"169","volume":"16","author":"Ma S","year":"2001","journal-title":"Chin Med Sci J"},{"key":"bibr51-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.11.055"},{"key":"bibr52-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1661554"},{"key":"bibr53-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.122969"},{"key":"bibr54-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/0301-2115(96)02484-0"},{"key":"bibr55-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2009.222"},{"key":"bibr56-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02882.x"},{"key":"bibr57-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2009.060"},{"key":"bibr58-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1996.tb00928.x"},{"key":"bibr59-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.06.024"},{"key":"bibr60-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15264.x"},{"key":"bibr61-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64127-2"},{"key":"bibr62-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg178"},{"key":"bibr63-10760296221126172","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051496"},{"key":"bibr64-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1646786"},{"key":"bibr65-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.08.059"},{"key":"bibr66-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.08.003"},{"key":"bibr67-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1136\/adc.58.9.739-a"},{"key":"bibr68-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90655-2"},{"key":"bibr69-10760296221126172","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2010.05.002"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296221126172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296221126172","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296221126172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:03:33Z","timestamp":1777385013000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296221126172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":69,"alternative-id":["10.1177\/10760296221126172"],"URL":"https:\/\/doi.org\/10.1177\/10760296221126172","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"10760296221126172"}}