{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:21:17Z","timestamp":1778901677055,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Liver health is essential for persons with hemophilia (PWH) in order to maintain access to new therapies, such as gene therapy. Non-alcoholic fatty liver disease (NAFLD) is seldom reported in the hemophilia population. The study aimed to investigate the prevalence of NAFLD and associated factors in PWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data of this cross-sectional study were obtained from a multicenter collaborative registry database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 163 moderate or severe PWH with a complete data of liver examination were analyzed. There were 77 (47.2%) PWH diagnosed with NAFLD. The multivariate analysis showed that overweight\/obesity was associated with NAFLD (OR, 4.31, P\u2009&lt;\u2009.001). In comparison with hemophilia B patients, hemophilia A patients showed a weaker correlation with NAFLD, (OR, 0.30, P\u2009=\u2009.009). A total of 17 (25.8%) PWH with NAFLD had an elevated level of alanine transaminase (ALT). Both overweight\/obesity and presence of inhibitor to clotting factor were independently associated with elevated ALT in PWH with NAFLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study indicated that a high prevalence of NAFLD existed in the hemophilia population. Overweight\/obesity was an independent factor for NAFLD and elevated ALT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296221128294","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:38:52Z","timestamp":1664239132000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence of non-Alcoholic Fatty Liver Disease and Associated Factors in Patients with Moderate or Severe Hemophilia: A Multicenter-Based Study"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7789-2148","authenticated-orcid":false,"given":"Ming-Ching","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Changhua Christian Hospital, Changhua"},{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyh-Shin","family":"Chiou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Chieh","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Te-Fu","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chung Shan Medical University Hospital, Taichung City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Yeh","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Changhua Christian Hospital, Changhua"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7908-4969","authenticated-orcid":false,"given":"Jiaan-Der","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Rare Disease and Hemophilia, Taichung Veterans General Hospital, Taichung City"},{"name":"Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shou-Wu","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Taichung Veterans General Hospital, Taichung City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Tien","family":"Peng","sequence":"additional","affiliation":[{"name":"Division of Pediatric Haematology and Oncology, China Medical University Children's Hospital, China Medical University, 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