{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:05:38Z","timestamp":1777478738614,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Introduction: Cerebral venous thrombosis (CVT) is a life-threatening neurological condition. There is limited evidence for the use of direct oral anticoagulants (DOAC) for long-term anticoagulation in this patient population. We report a case series of patients treated with apixaban and their clinical course. Methods: This was a retrospective cohort study. Patients diagnosed with CVT in a defined time period at our institution were screened for long-term anticoagulation and patients who were treated with apixaban were included in this study. Results: A total of nine patients were included in this study. The mean age was 36 years and 56% of the patients included were women. All received initial anticoagulation with unfractionated heparin (UFH) infusion for at least twenty-four hours, except for one patient who had anti-thrombin III deficiency and was treated with argatroban infusion. For long-term anticoagulation, 56% of patients received apixaban 10\u2005mg twice daily for the first five to seven days followed by 5\u2005mg twice daily, while the remaining 44% were transitioned from IV anticoagulation to apixaban 5\u2005mg twice daily. There were no adverse events reported, except for one patient who developed anemia after 7 months of treatment and required a blood transfusion. Complete recanalization was achieved in 78% while 22% had partial recanalization. Follow-up time ranged from six to twenty-three months. Conclusion: The use of apixaban for long-term anticoagulation in CVT resulted in recanalization in all of the patients in this case series without any major side effects. This case series adds to the emerging studies demonstrating the utility of apixaban for CVT.<\/jats:p>","DOI":"10.1177\/10760296221129591","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T02:35:17Z","timestamp":1674700517000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Long-term Anticoagulation with Apixaban in Patients with Cerebral Venous Thrombosis"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9871-3580","authenticated-orcid":false,"given":"Suman Preet","family":"Bharath","sequence":"first","affiliation":[{"name":"Division of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasnain","family":"Arshad","sequence":"additional","affiliation":[{"name":"Division of Neurology, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Bum","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Hackensack Meridian Health JFK University Medical Center, Edison, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jawad F.","family":"Kirmani","sequence":"additional","affiliation":[{"name":"Division of Neurology, Hackensack Meridian Health JFK University Medical Center, Edison, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"bibr1-10760296221129591","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e31820a8364"},{"key":"bibr2-10760296221129591","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90607-q"},{"key":"bibr3-10760296221129591","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13381"},{"key":"bibr4-10760296221129591","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.055"},{"key":"bibr5-10760296221129591","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302507"},{"key":"bibr6-10760296221129591","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2764"},{"key":"bibr7-10760296221129591","doi-asserted-by":"publisher","DOI":"10.1097\/nrl.0000000000000049"},{"key":"bibr8-10760296221129591","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207541"},{"key":"bibr9-10760296221129591","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.11.018"},{"key":"bibr10-10760296221129591","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.09.007"},{"key":"bibr11-10760296221129591","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020952749"},{"key":"bibr12-10760296221129591","doi-asserted-by":"publisher","DOI":"10.5603\/PJNNS.a2019.0037"},{"key":"bibr13-10760296221129591","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.121.037541"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296221129591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296221129591","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296221129591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:03:42Z","timestamp":1777385022000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296221129591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":13,"alternative-id":["10.1177\/10760296221129591"],"URL":"https:\/\/doi.org\/10.1177\/10760296221129591","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"10760296221129591"}}