{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:13:22Z","timestamp":1793312002287,"version":"4.5.0"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The study investigates the diagnostic and prognostic significance of the prothrombin time\/international normalized ratio (PT\/INR) in patients with sepsis and septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis may be complicated by disseminated intravascular coagulation (DIC). While the status of coagulopathy of septic patients is represented within the sepsis-3 definition by assessing the platelet count, less data regarding the prognostic impact of the PT\/INR in patients admitted with sepsis and septic shock is available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients with sepsis and septic shock from 2019 to 2021 were included. Blood samples were retrieved from day of disease onset (ie, day 0), as well as on day 1, 2, 4, 6 and 9 thereafter. Firstly, the diagnostic value of the PT\/INR in comparison to the activated partial thromboplastin time (aPTT) was tested for septic shock compared to sepsis without shock. Secondly, the prognostic value of the PT\/INR for 30-day all-cause mortality was tested. Statistical analyses included univariable t-tests, Spearman's correlations, C-statistics, Kaplan-Meier analyses and Cox proportional regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>338 patients were included (56% sepsis without shock, 44% septic shock). The overall rate of all-cause mortality at 30 days was 52%. With an area under the curve (AUC) of 0.682 ( p= .001) on day 0, the PT\/INR revealed moderate discrimination of septic shock and sepsis without shock. Furthermore, PT\/ INR was able to discriminate non-survivors and survivors at 30 days (AUC\u2009=\u20090.612; p\u2009=\u2009.001). Patients with a PT\/INR &gt;1.5 had higher rates of 30-day all-cause mortality than patients with lower values (mortality rate 73% vs 48%; log rank p\u2009=\u2009.001; HR\u2009=\u20092.129; 95% CI 1.494-3.033; p\u2009=\u2009.001), even after multivariable adjustment (HR\u2009=\u20091.793; 95% CI 1.343-2.392; p\u2009=\u2009.001). Increased risk of 30-day all-cause mortality was observed irrespective of concomitant thrombocytopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The PT\/INR revealed moderate diagnostic accuracy for septic shock but was associated with reliable prognostic accuracy with regard to 30-day all-cause mortality in patients admitted with sepsis and septic shock.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296221137893","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T05:30:00Z","timestamp":1670823000000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Diagnostic and Prognostic Significance of the Prothrombin Time\/International Normalized Ratio in Sepsis and Septic Shock"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8171-7617","authenticated-orcid":false,"given":"Tobias","family":"Schupp","sequence":"first","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"},{"name":"European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) partner site Heidelberg\/Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Weidner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"},{"name":"European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) partner site Heidelberg\/Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Rusnak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"},{"name":"European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) partner site Heidelberg\/Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schanas","family":"Jawhar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"},{"name":"European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) partner site Heidelberg\/Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Forner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"},{"name":"European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) partner site Heidelberg\/Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriana","family":"Dulatahu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"},{"name":"European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) partner site Heidelberg\/Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea Marie","family":"Br\u00fcck","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"},{"name":"European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) partner site Heidelberg\/Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"},{"name":"European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) partner site Heidelberg\/Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bertsch","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Nuremberg General Hospital, Paracelsus Medical University, Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Clinic for Interventional Electrophysiology, Heart Centre Bad Neustadt, Bad Neustadt a. d. Saale, Germany"},{"name":"Department of Cardiology and Angiology, Philipps-University Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Wei\u00df","sequence":"additional","affiliation":[{"name":"Department of Statistical Analysis, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"},{"name":"European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) partner site Heidelberg\/Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Behnes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"},{"name":"European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) partner site Heidelberg\/Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"bibr1-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000026"},{"key":"bibr2-10760296221137893","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.08.59"},{"key":"bibr3-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"bibr4-10760296221137893","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102200"},{"key":"bibr5-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000295317.97245.2D"},{"key":"bibr6-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.5358"},{"key":"bibr7-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202290"},{"key":"bibr8-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-680744"},{"key":"bibr9-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002919"},{"key":"bibr10-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14482"},{"key":"bibr11-10760296221137893","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19116626"},{"key":"bibr12-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.148.3.6878708"},{"key":"bibr13-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2015.02.010"},{"key":"bibr14-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-017046"},{"key":"bibr15-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200204000-00005"},{"key":"bibr16-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-013-0545-5"},{"key":"bibr17-10760296221137893","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i25.7405"},{"key":"bibr18-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1718736"},{"key":"bibr19-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1177\/1076029618806424"},{"key":"bibr20-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12221"},{"key":"bibr21-10760296221137893","doi-asserted-by":"publisher","DOI":"10.5847\/wjem.j.issn.1920-8642.2014.03.006"},{"key":"bibr22-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000981"},{"key":"bibr23-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2020.0189"},{"key":"bibr24-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79843-5"},{"key":"bibr25-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002997"},{"key":"bibr26-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0507-z"},{"key":"bibr27-10760296221137893","doi-asserted-by":"publisher","DOI":"10.2174\/1389201018666170601080111"},{"issue":"6","key":"bibr28-10760296221137893","first-page":"999","volume":"64","author":"Hamed S","year":"2018","journal-title":"Clin Lab"},{"key":"bibr29-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.03.050"},{"key":"bibr30-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocpiqo.2019.10.008"},{"key":"bibr31-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-019-0609-3"},{"key":"bibr32-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2021.07.009"},{"key":"bibr33-10760296221137893","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108542"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296221137893","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296221137893","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296221137893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:03:38Z","timestamp":1777385018000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296221137893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":33,"alternative-id":["10.1177\/10760296221137893"],"URL":"https:\/\/doi.org\/10.1177\/10760296221137893","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"10760296221137893"}}