{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:30:08Z","timestamp":1793363408685,"version":"4.5.0"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dipeptidyl peptidase 3 (DPP-3) is an intracellular enzyme that causes hemodynamic instability and cardiac depression in several cases such as cardiogenic shock, sepsis and burns where DPP-3 is released into the blood due to cell death. Data on the effect of higher DPP-3 levels on acute coronary syndrome (ACS) patients are currently lacking. The aim of this study was to evaluate the effect of DPP-3 levels on ACS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective study, we included ACS patients including STEMI and non-STEMI groups and a control group to compare various demographic, echocardiographic and laboratory parameters including DPP-3. DPP-3 levels were measured at 24\n                      <jats:sup>th<\/jats:sup>\n                      , 48\n                      <jats:sup>th<\/jats:sup>\n                      , and 72\n                      <jats:sup>nd<\/jats:sup>\n                      h from the onset of symptoms in ACS patients and then compared with left ventricle ejection fraction (LVEF) for the assessment of left ventricle systolic function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 70 ACS patients (age 62.5\u2009\u00b1\u200911 years, 68.6% male) were recruited and 48 normal individuals were included as control group (age 61.1\u2009\u00b1\u200910 years, 66.7% male). It has been demonstrated that DPP-3 levels are significantly higher in the ACS group than the control group like troponin I levels. DPP-3 levels were found to be one of the independent predictors of LVEF similar to NT-proBNP and troponin I.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests that DPP-3 could be an important indicator of myocardial depression predicting left ventricle systolic function in ACS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296221145174","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T01:07:59Z","timestamp":1670980079000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: \u2018DPP-3\u2019"],"prefix":"10.1177","volume":"28","author":[{"given":"Ozge","family":"Ozden","sequence":"first","affiliation":[{"name":"Department of Cardiology, Bahcelievler Memorial Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuma","family":"Yesildas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mersin University Medical Faculty, Mersin, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mersin University Medical Faculty, Mersin, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-7798","authenticated-orcid":false,"given":"Ali Orcun","family":"Surmeli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mersin University Medical Faculty, Mersin, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrah","family":"Yesil","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bahcelievler Memorial Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozcan","family":"Orscelik","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mersin University Medical Faculty, Mersin, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9417-7610","authenticated-orcid":false,"given":"Ahmet","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mersin University Medical Faculty, Mersin, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"bibr1-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2017.04.018"},{"key":"bibr2-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"bibr3-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1601"},{"key":"bibr4-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)33674-3"},{"key":"bibr5-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08275.x"},{"key":"bibr6-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03471-2"},{"key":"bibr7-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1649"},{"key":"bibr8-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02888-5"},{"key":"bibr9-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1600"},{"key":"bibr10-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezaa413"},{"key":"bibr11-10760296221145174","doi-asserted-by":"publisher","DOI":"10.2174\/1389203718666170329104936"},{"key":"bibr12-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-8-65"},{"key":"bibr13-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1515\/bchm3.1988.369.1.29"},{"key":"bibr14-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014943522613"},{"key":"bibr15-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1373\/jalm.2018.027995"},{"key":"bibr16-10760296221145174","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238039"}],"container-title":["Clinical 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