{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:24:16Z","timestamp":1784053456655,"version":"3.55.0"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Helsinki University Hospital"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Chronic thromboembolic pulmonary hypertension (CTEPH) is associated with thrombotic states including elevated coagulation factor VIII (FVIII). Pulmonary endarterectomy (PEA) is the main treatment for CTEPH, and efficient anticoagulation is essential to prevent thromboembolism recurrence after surgery. We aimed to characterize longitudinal changes in FVIII and other coagulation biomarkers after PEA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Coagulation biomarker levels were measured at baseline and up to 12 months after operation in 17 consecutive patients with PEA. Temporal patterns of coagulation biomarkers, and correlation of FVIII with other coagulation biomarkers, were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Baseline FVIII levels were elevated in 71% of the patients (mean 216\u2009\u00b1\u200967 IU\/dl). FVIII doubled 7 days after PEA, peaking at 471\u2009\u00b1\u200987 IU\/dl, and gradually returned to respective baseline levels within 3 months. Postoperative fibrinogen levels were also elevated. Antithrombin decreased at 1 to 3 days, D-dimer increased at 1 to 4 weeks, and thrombocytosis was observed at 2 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FVIII is elevated in most patients with CTEPH. After PEA, early but transient elevation of FVIII and fibrinogen, and delayed reactive thrombocytosis, occurs, and warrants careful postoperative anticoagulation to prevent thromboembolism recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296231158369","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T01:35:36Z","timestamp":1678325736000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Upregulation of Coagulation Factor VIII and Fibrinogen After Pulmonary Endarterectomy in Patients with Chronic Thromboembolic Pulmonary Hypertension"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7462-3003","authenticated-orcid":false,"given":"Lasse","family":"Myllylahti","sequence":"first","affiliation":[{"name":"Division of Internal Medicine, Department of Internal Medicine and Rehabilitation, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Ropponen","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Lax","sequence":"additional","affiliation":[{"name":"Division of Anesthesiology, Department of Anesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riitta","family":"Lassila","sequence":"additional","affiliation":[{"name":"Unit of Coagulation Disorders, Department of Hematology, Comprehensive Cancer Center, Helsinki University Hospital, and Research Program Unit in Systems Oncology, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti I.","family":"Nyk\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"bibr1-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01915-2018"},{"key":"bibr2-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01792-2016"},{"key":"bibr3-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00087608"},{"key":"bibr4-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.01.012"},{"key":"bibr5-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-02-0067"},{"key":"bibr6-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01805-2018"},{"key":"bibr7-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15b28.x"},{"key":"bibr8-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-208264"},{"key":"bibr9-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-916OC"},{"key":"bibr10-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304404"},{"key":"bibr11-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2015.12.001"},{"key":"bibr12-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(83)90033-6"},{"key":"bibr13-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.05.028"},{"key":"bibr14-10760296231158369","author":"Nyk\u00e4nen AI","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"bibr15-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09134.x"},{"key":"bibr16-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1981755"},{"key":"bibr17-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-021-00324-4"},{"key":"bibr18-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.10.028"},{"issue":"2","key":"bibr19-10760296231158369","first-page":"216","volume":"84","author":"Begbie M","year":"2000","journal-title":"Thromb Haemost"},{"issue":"1","key":"bibr20-10760296231158369","first-page":"R49","volume":"257","author":"Noe DA","year":"1989","journal-title":"Am J Physiol"},{"key":"bibr21-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614223"},{"key":"bibr22-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202109-2075OC"},{"key":"bibr23-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1248720"},{"key":"bibr24-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2003.2"},{"key":"bibr25-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(02)00195-8"},{"key":"bibr26-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.16-595"},{"key":"bibr27-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00134-X"},{"key":"bibr28-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(05)80172-1"},{"key":"bibr29-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.9.2720"},{"key":"bibr30-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02828-2020"},{"key":"bibr31-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000151647.14923.ec"},{"key":"bibr32-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.10.026"},{"key":"bibr33-10760296231158369","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e31827e4e62"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296231158369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296231158369","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296231158369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:03:47Z","timestamp":1777385027000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296231158369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":33,"alternative-id":["10.1177\/10760296231158369"],"URL":"https:\/\/doi.org\/10.1177\/10760296231158369","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"10760296231158369"}}