{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:08:26Z","timestamp":1777478906529,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018853","name":"Prince Charles Hospital Foundation","doi-asserted-by":"publisher","award":["INN 2018-47 and Equipment grant"],"award-info":[{"award-number":["INN 2018-47 and Equipment grant"]}],"id":[{"id":"10.13039\/501100018853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    The prothrombotic state of obesity can increase the risk of thromboembolism. We aimed to investigate if there was an association between baseline hypercoagulable rotational thromboelastometry (ROTEM) profile and thromboembolic complications in arthroplasty patients with obesity. Patients with a body mass index \u2265\u200925\u2005kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    and\/or waist circumference \u226594\u2005cm (M) and 80\u2005cm (F) undergoing hip and knee arthroplasty had pre- and postoperative ROTEM. ROTEM values were compared by outcome status using an independent sample equal-variance t-test. Of the 303 total participants, hypercoagulability defined as extrinsically activated thromboelastometry maximum clot firmness G score\u2009\u2265\u200911\u2005K dyne\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , was observed in 90 (30%) of the 300 participants with preoperative ROTEM assays. Clinically significant thromboembolic complications occurred in 5 (1.7%) study participants before discharge and in 10 (3.3%) by 90 days. These included 6 with pulmonary emboli, 3 with deep venous thrombus, and 1 with myocardial infarction. We found no evidence for an association between baseline hypercoagulability and incident thromboembolic events, analysis limited by the number of events. Postoperative decrease in platelets and an increase in fibrinogen were observed. ROTEM parameter changes differed across obesity categories.\n                  <\/jats:p>","DOI":"10.1177\/10760296231199737","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T02:48:54Z","timestamp":1696906134000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Thromboelastometry Identified Hypercoagulability and Thromboembolic Complications After Arthroplasty: A Prospective Observational Study in Patients With Obesity"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0336-872X","authenticated-orcid":false,"given":"Usha","family":"Gurunathan","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Perfusion Services, The Prince Charles Hospital, Brisbane, QLD, Australia"},{"name":"Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lily","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Perfusion Services, The Prince Charles Hospital, Brisbane, QLD, Australia"},{"name":"Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Hines","sequence":"additional","affiliation":[{"name":"Adult Intensive Care Unit, The Prince Charles Hospital, Brisbane, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bronwyn","family":"Pearse","sequence":"additional","affiliation":[{"name":"Blood Management Unit, The Prince Charles Hospital, Brisbane, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia"},{"name":"Department of Cardiology, The Prince Charles Hospital, Brisbane, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Hay","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia"},{"name":"QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Mullany","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Perfusion Services, The Prince Charles Hospital, Brisbane, QLD, Australia"},{"name":"Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshal","family":"Nandurkar","sequence":"additional","affiliation":[{"name":"Department of Haematology, Alfred Health, Melbourne, VIC, Australia"},{"name":"Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Eley","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia"},{"name":"Department of Anaesthesia and Perioperative Medicine, The Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"bibr1-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-020-3100-4"},{"key":"bibr2-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2022.03.003"},{"key":"bibr3-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2022.01.087"},{"key":"bibr4-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-015-2208-8"},{"key":"bibr5-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304085"},{"key":"bibr6-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"bibr7-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3283634443"},{"key":"bibr8-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.171016"},{"key":"bibr9-10760296231199737","first-page":"525374","volume":"2012","author":"Russo I","year":"2012","journal-title":"Scientifica (Cairo)"},{"key":"bibr10-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.10522"},{"key":"bibr11-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.08.022"},{"key":"bibr12-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000490"},{"key":"bibr13-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2016.02.077"},{"key":"bibr14-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0549-2"},{"key":"bibr15-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X19864114"},{"key":"bibr16-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000001832"},{"key":"bibr17-10760296231199737","unstructured":"IDF Consensus Worldwide Definition of the Metabolic Syndrome 2006. https:\/\/www.idf.org\/e-library\/consensus-statements\/60-idfconsensus-worldwide-definitionof-the-metabolic-syndrome.html. Accessed February 20, 2020."},{"key":"bibr18-10760296231199737","unstructured":"World Health Organisation. Waist Circumference and Waist\u2013Hip Ratio: Report of a WHO Expert Consultation. Geneva 8-11 December 2008. 2011. https:\/\/www.who.int\/publications\/i\/item\/9789241501491. https:\/\/www.who.int\/publications\/i\/item\/9789241501491. Accessed May 28, 2021."},{"key":"bibr19-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1779"},{"key":"bibr20-10760296231199737","unstructured":"World Health Organisation: Health topics: Body Mass index. https:\/\/www.euro.who.int\/en\/health-topics\/disease-prevention\/nutrition\/a-healthy-lifestyle\/body-mass-index-bmi. https:\/\/www.euro.who.int\/en\/health-topics\/disease-prevention\/nutrition\/a-healthy-lifestyle\/body-mass-index-bmi. Accessed July 26, 2020."},{"key":"bibr21-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5224-7"},{"key":"bibr22-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-3203-1"},{"key":"bibr23-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23599"},{"key":"bibr24-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02130-7"},{"key":"bibr25-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.01.003"},{"key":"bibr26-10760296231199737","unstructured":"Preliminary reference ranges ROTEM\u00ae sigma. Instrumentation Laboratory. Edition 2017-04-20.Copyright \u00a9 2017 Tem Innovations GmBH. Based on https:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT02379104. Accessed December 20, 2021."},{"key":"bibr27-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000155290.86795.12"},{"key":"bibr28-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12992"},{"key":"bibr29-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.13416"},{"key":"bibr30-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017103"},{"key":"bibr31-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12678"},{"key":"bibr32-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4583"},{"key":"bibr33-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000153938.77777.26"},{"key":"bibr34-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-18-40"},{"key":"bibr35-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001414"},{"key":"bibr36-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1159\/000468946"},{"key":"bibr37-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.09.157"},{"key":"bibr38-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2016.06.027"},{"key":"bibr39-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.01.012"},{"key":"bibr40-10760296231199737","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.08.046"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296231199737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296231199737","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296231199737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:04:10Z","timestamp":1777385050000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296231199737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":40,"alternative-id":["10.1177\/10760296231199737"],"URL":"https:\/\/doi.org\/10.1177\/10760296231199737","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"10760296231199737"}}