{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:08:26Z","timestamp":1777478906307,"version":"3.51.4"},"reference-count":77,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008249","name":"Frimodt-Heineke Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008249","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Murermester Lauritz Peter Christensen og hustru Kirsten Sigrid Christensens Fond","award":["3051415 jhj\/mj\/is"],"award-info":[{"award-number":["3051415 jhj\/mj\/is"]}]},{"name":"Regionshopitalet Randers\u2019 spiremidler 2020"},{"DOI":"10.13039\/501100004331","name":"Snedkermester Sophus Jacobsen og Hustru Astrid Jacobsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D deficiency has recently been suggested as an independent risk factor for thrombosis. Notably, vitamin D deficiency is common in pregnant populations, whom already have an increased thrombotic risk. However, pregnant women are commonly excluded from studies investigating the hemostatic system, and knowledge on the impact of vitamin D on hemostasis in pregnancy is therefore limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study comparing the hemostatic profile of pregnant women (gestational week 12.9\u2009\u00b1\u20090.7) with vitamin D deficiency (\u226450\u2005nmol\/L) (n\u2009=\u200970) and high adequate vitamin D status (\u2265100\u2005nmol\/L) (n\u2009=\u200959).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Vitamin D deficient women displayed increased plasminogen activator inhibitor 1 levels and an increased plasminogen activator inhibitor 1\/plasminogen activator inhibitor 2 ratio, even after adjusting for factors with potential influence on hemostasis (body mass index, smoking and use of fish oil supplements).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vitamin D deficiency is associated with increased plasminogen activator inhibitor 1\/plasminogen activator inhibitor 2 ratio in pregnant women. As an increased plasminogen activator inhibitor 1\/plasminogen activator inhibitor 2 ratio with high plasminogen activator inhibitor 1 levels may increase thrombotic risk and is associated with the development of pregnancy complications, further research is needed to determine the optimal vitamin D supplementation in pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296231201855","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T20:50:33Z","timestamp":1695070233000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Vitamin D Deficiency is Associated With Increased Plasminogen Activator Inhibitor 1\/Plasminogen Activator Inhibitor 2 Ratio in Pregnancy"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2950-8288","authenticated-orcid":false,"given":"Matilde 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Inflammation, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar","family":"Bor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Randers Regional Hospital, Randers, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnete","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Vakur","family":"Bor","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, Thrombosis Research, University of Southern Denmark, Esbjerg, Denmark"},{"name":"Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, 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