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However, the thrombotic state in ACI cannot be evaluated using routine hemostatic examinations. Plasma soluble C-type lectin-like receptor 2 (sCLEC-2) and D-dimer levels were measured in patients with ACI. Plasma sCLEC-2 and D-dimer levels were significantly higher in patients with ACI than in those without it. The sCLEC-2\u2009\u00d7\u2009D-dimer formula was significantly higher in patients with ACI than in those without it. A receiver operating characteristic curve showed a high sensitivity, area under the curve, and odds for diagnosing ACI in the sCLEC-2\u2009\u00d7\u2009D-dimer formula. Although the sCLEC-2 and D-dimer levels were useful for the differential diagnosis between cardiogenic and atherosclerotic ACI, the sCLEC-2\u2009\u00d7\u2009D-dimer formula was not useful. sCLEC2 and D-dimer levels are useful for the diagnosis of ACI and the sCLEC2\u2009\u00d7\u2009D-dimer formula can enhance the diagnostic ability of ACI, and sCLEC2 and D-dimer levels may be useful for differentiating between atherosclerotic and cardioembolic ACI.<\/jats:p>","DOI":"10.1177\/10760296241232858","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:27:23Z","timestamp":1708907243000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Super Formula for Soluble C-Type  Lectin-Like Receptor 2\u2009\u00d7\u2009D-Dimer in  Patients With Acute Cerebral Infarction"],"prefix":"10.1177","volume":"30","author":[{"given":"Toshitaka","family":"Kamon","sequence":"first","affiliation":[{"name":"Department of Neurology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9021-8633","authenticated-orcid":false,"given":"Hideo","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of General and Laboratory Medicine, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Shiraki","sequence":"additional","affiliation":[{"name":"Department of General and Laboratory Medicine, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhuko","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Ezaki","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motomu","family":"Shimaoka","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akisato","family":"Nishigaki","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Shindo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideto","family":"Shimpo","sequence":"additional","affiliation":[{"name":"Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,25]]},"reference":[{"key":"bibr1-10760296241232858","volume":"368","author":"Phipps MS","year":"2020","journal-title":"Br Med J."},{"key":"bibr2-10760296241232858","unstructured":"World stroke organization (WSO). 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