{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:55:42Z","timestamp":1780462542751,"version":"3.54.1"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), represents a substantial healthcare challenge. Provoked and unprovoked DVT cases carry distinct risks and treatment considerations. Recognizing the limitations of this classification, molecular markers may enhance diagnostic precision and guide anticoagulation therapy duration relying on patient history and risk factors. This preliminary, open-label, prospective cohort study was conducted including 15 patients (10 provoked DVT and 5 unprovoked DVT) and a control group of healthy plasmatic subjects. Plasma levels of 9 biomarkers were measured at diagnosis (baseline, day 0, and D0) and after 30 days (day 30-D30). Patient demographics, clinical data, and biomarker concentrations were analyzed. Serum concentrations of D-dimer, von Willebrand factor, C-reactive protein, and Anti-Xa were elevated in DVT groups at D0 compared to controls. No significant differences were observed between the provoked and unprovoked groups on the day of diagnosis and 30 days later. Over 30 days, the provoked group exhibited significant biomarker changes related to temporal assessment. No significant differences were noted in the biomarker profile between provoked and unprovoked DVT groups. This study is indicative of the concept of individualized thrombosis assessment and subsequent treatment for VTE. Larger cohorts are warranted to validate these findings and further define the most appropriate use of the molecular markers.<\/jats:p>","DOI":"10.1177\/10760296241238211","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T03:33:20Z","timestamp":1712115200000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Biomarkers Profile in Provoked\n                    <i>Versus<\/i>\n                    Unprovoked Deep Venous Thrombosis"],"prefix":"10.1177","volume":"30","author":[{"given":"Isabela Rodrigues","family":"Tavares","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Santa Casa de S\u00e3o Paulo School of Medical Sciences, S\u00e3o Paulo, SP, Brazil"},{"name":"Dante Pazzanese Cardiology Institute, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Augusto","family":"Caffaro","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Santa Casa de S\u00e3o Paulo School of Medical Sciences, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda","family":"Portugal","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Hospital Israelita Albert Einstein, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla Moreira","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Science Valley Research Institute, Santo Andr\u00e9, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane Santana","family":"da Silva","sequence":"additional","affiliation":[{"name":"Science Valley Research Institute, Santo Andr\u00e9, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Krupa","sequence":"additional","affiliation":[{"name":"Pathology Department, Hemostasis & Thrombosis Research Laboratories at Loyola University Medical Center, Maywood, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3142-2199","authenticated-orcid":false,"given":"Srdjan","family":"Nikolovski","sequence":"additional","affiliation":[{"name":"Pathology Department, Hemostasis & Thrombosis Research Laboratories at Loyola University Medical Center, Maywood, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Falc\u00e3o","family":"de Britto","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Santa Casa de S\u00e3o Paulo School of Medical Sciences, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cl\u00e1udia","family":"Gomes Pereira Petisco","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Cardiology Institute, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Miranda","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Cardiology Institute, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Gomes de Souza Santos","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Cardiology Institute, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"da Silva Dourado","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Cardiology Institute, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Veloso","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Cardiology Institute, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fakiha","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Pathology Department, Hemostasis & Thrombosis Research Laboratories at Loyola University Medical Center, Maywood, IL, USA"},{"name":"Program in Health Sciences. 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