{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:10:22Z","timestamp":1777479022675,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>In unfractionated heparin (UFH) monitoring during extracorporeal circulation, the traditional measures of activated clotting time (ACT) or activated partial thromboplastin time (APTT) may diverge, confounding anticoagulant adjustments. We aimed to explore the factors explaining this discrepancy in children and young adults. This retrospective observational study, conducted at an urban regional tertiary hospital, included consecutive pediatric patients who received UFH during extracorporeal circulation (continuous kidney replacement therapy or extracorporeal membrane oxygenation) between April 2017 and March 2021. After patients whose ACT and APTT were not measured simultaneously or who were also taking other anticoagulants were excluded, we analyzed 94 samples from 23 patients. To explain the discrepancy between ACT and APTT, regression equations were created using a generalized linear model (family\u2009\u2009=\u2009\u2009gamma, link\u2009\u2009=\u2009\u2009logarithmic) with ACT as the response variable. Other explanatory variables included age, platelet count, and antithrombin. Compared to APTT alone as an explanatory variable, the Akaike information criterion and pseudo-coefficient of determination improved from 855 to 625 and from 0.01 to 0.42, respectively, when these explanatory variables were used. In conclusion, we identified several factors that may explain some of the discrepancy between ACT and APTT in the routinely measured tests. Evaluation of these factors may aid in appropriate adjustments in anticoagulation therapy.<\/jats:p>","DOI":"10.1177\/10760296241252838","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T02:03:55Z","timestamp":1715047435000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors Affecting the Discrepancy Between Coagulation Times on Extracorporeal Circulation Using Unfractionated Heparin in Children and Young Adults"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-6479","authenticated-orcid":false,"given":"Taiki","family":"Haga","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Osaka City General Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yotaro","family":"Misaki","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Osaka City General Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Osaka City General Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Akamine","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Osaka City General Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"bibr1-10760296241252838","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.athoracsur.2015.07.046","volume":"101","author":"Mazzeffi M","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"bibr2-10760296241252838","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1513\/AnnalsATS.201605-364SR","volume":"13","author":"Sklar MC","year":"2016","journal-title":"Ann Am Thorac Soc"},{"key":"bibr3-10760296241252838","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/cc5937","volume":"11","author":"Joannidis M","year":"2007","journal-title":"Crit Care"},{"key":"bibr4-10760296241252838","unstructured":"Extracorporeal Life Support Organization. ELSO anticoagulation guideline; 2014. Available from: https:\/\/www.elso.org\/Portals\/0\/Files\/elsoanticoagulationguideline8-2014-table-contents.pdf. (Accessed 20 November 2023)."},{"key":"bibr5-10760296241252838","doi-asserted-by":"crossref","DOI":"10.1097\/PCC.0000000000000008","volume":"14","author":"Bembea MM","year":"2013","journal-title":"Pediatr Crit Care Med"},{"key":"bibr6-10760296241252838","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/PCC.0000000000002696","volume":"22","author":"Ozment CP","year":"2021","journal-title":"Pediatr Crit Care Med"},{"key":"bibr7-10760296241252838","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/0267659116637420","volume":"31","author":"Cunningham D","year":"2016","journal-title":"Perfusion"},{"key":"bibr8-10760296241252838","doi-asserted-by":"crossref","DOI":"10.1097\/MJT.0000000000001113","volume":"29","author":"Hohlfelder B","year":"2022","journal-title":"Am J Ther"},{"key":"bibr9-10760296241252838","volume":"13","author":"Maul TM","year":"2012","journal-title":"Pediatr Crit Care Med"},{"key":"bibr10-10760296241252838","unstructured":"Extracorporeal Life Support Organization: ELSO Anticoagulation Guideline 2014. Available at https:\/\/www.elso.org\/Portals\/0\/Files\/elsoanticoagulationguideline8-2014-table-contents.pdf. Accessed March 19, 2024"},{"key":"bibr11-10760296241252838","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.athoracsur.2006.09.054","volume":"83","author":"Baird CW","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"bibr12-10760296241252838","unstructured":"Teruya J. Coagulation tests affected by acute phase reactants such as CRP and factor VIII. Paper presented at:\n                      International Conference on Hematology & Blood Disorders\n                      ; September 23-25, 2013; RTP, NC, USA."},{"key":"bibr13-10760296241252838","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1055\/s-0038-1657138","volume":"47","author":"Peterson P","year":"1982","journal-title":"Thromb Haemost"},{"key":"bibr14-10760296241252838","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1055\/s-0039-1678719","volume":"45","author":"Favaloro EJ","year":"2019","journal-title":"Semin Thromb Hemost"},{"key":"bibr15-10760296241252838","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","volume":"370","author":"Von Elm E","year":"2007","journal-title":"Lancet"},{"key":"bibr16-10760296241252838","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.pcl.2013.08.003","volume":"60","author":"Jaffray J","year":"2013","journal-title":"Pediatr Clin North Am"},{"key":"bibr17-10760296241252838","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1055\/s-0037-1615947","volume":"85","author":"Hoffman M","year":"2001","journal-title":"Thromb Haemost"},{"key":"bibr18-10760296241252838","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1080\/09537104.2019.1704713","volume":"31","author":"Dias JD","year":"2020","journal-title":"Platelets"},{"key":"bibr19-10760296241252838","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11748-020-01435-x","volume":"69","author":"Matsushita S","year":"2021","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"bibr20-10760296241252838","doi-asserted-by":"crossref","first-page":"129","DOI":"10.21037\/acs.2018.07.03","volume":"8","author":"Koster A","year":"2019","journal-title":"Ann Cardiothorac Surg"},{"key":"bibr21-10760296241252838","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1177\/0267659114524264","volume":"29","author":"Atallah S","year":"2014","journal-title":"Perfusion"},{"key":"bibr22-10760296241252838","volume":"13","author":"Timothy M","year":"2012","journal-title":"Pediatr Crit Care Med"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296241252838","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296241252838","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296241252838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:04:36Z","timestamp":1777385076000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296241252838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":22,"alternative-id":["10.1177\/10760296241252838"],"URL":"https:\/\/doi.org\/10.1177\/10760296241252838","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"10760296241252838"}}