{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:10:54Z","timestamp":1777479054893,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Scientific Research Launch Project for new employees of the Second Xiangya Hospital of Central South University"},{"name":"the National Key Clinical Specialty Construction Projects of China"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    To investigate the association between heart rate (HR) at diagnosis and long-term pulmonary embolism (PE) recurrence among elderly (\u2265 50 year-old) female patients after acute PE (APE). Hospitalized patients with APE were grouped separately according to whether they experienced recurrent PE and whether the HR was \u2009&lt;\u200980 beats\/min. Logistic regression and COX regression analysis were employed to assess the risk of PE recurrence. Kaplan\u2013Meier method was applied to compare the recurrence-free survival of PE recurrence. Eighty-five patients were included, including 24 ones with HR\u2009&lt;\u200980 beats\/min and 11 recurrent PE cases. The mean time of PE recurrence were 71.7\u2009\u00b1\u200926.9 months (n\u2009=\u20096) and 27.7\u2009\u00b1\u200925.2 months (n\u2009=\u20095) among the patients with low HR and with high HR, respectively ( P\u2009&lt;\u2009.001). The HR (&lt; 80 beats\/min) was a negative predictor of PE recurrence (OR 0.071 (0.090-0.572), P\u2009=\u2009.013; HR 0.091 (0.016-0.523), P\u2009=\u2009.007), even after the adjustment for age, BMI, albumin, risk stratification, surgery, immobility\u2009\u2265\u20094 days, the blood cells counts, bilirubin and complications. The cumulative recurrence-free rates of PE recurrence at the 1\n                    <jats:sup>st<\/jats:sup>\n                    -, 2\n                    <jats:sup>nd<\/jats:sup>\n                    -, 5\n                    <jats:sup>th<\/jats:sup>\n                    -, and 10\n                    <jats:sup>th<\/jats:sup>\n                    -years for the low HR group were 100%, 100%, 87.5%, and 58.3%, compared to the 1\n                    <jats:sup>st<\/jats:sup>\n                    -, 2\n                    <jats:sup>nd<\/jats:sup>\n                    -, and 3\n                    <jats:sup>rd<\/jats:sup>\n                    -years of 94.0%, 93.4%, and 48.0% for the high HR group (log-rank\u2009=\u20090.019). The low HR (&lt; 80 beats\/min at diagnosis) among elderly (\u2265 50 years old) female patients at APE diagnosis would benefit to the long-term PE recurrence. But limited recurrent cases should be noted.\n                  <\/jats:p>","DOI":"10.1177\/10760296241268432","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T05:49:57Z","timestamp":1721972997000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Heart Rate at Diagnosis and Long-Term Recurrence Risk of Pulmonary Embolism in a Historical Cohort Study of Elder Women"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7233-2720","authenticated-orcid":false,"given":"Yuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Clinical Medical Research Center for Pulmonary and Critical Care Medicine, Changsha, Hunan Province, China"},{"name":"Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Hunan Evidence-based Medicine Center, Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Clinical Medical Research Center for Pulmonary and Critical Care Medicine, Changsha, Hunan Province, China"},{"name":"Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Hunan Evidence-based Medicine Center, Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meizhi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Clinical Medical Research Center for Pulmonary and Critical Care Medicine, Changsha, Hunan Province, China"},{"name":"Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Hunan Evidence-based Medicine Center, Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Clinical Medical Research Center for Pulmonary and Critical Care Medicine, Changsha, Hunan Province, China"},{"name":"Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Hunan Evidence-based Medicine Center, Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Clinical Medical Research Center for Pulmonary and Critical Care Medicine, Changsha, Hunan Province, China"},{"name":"Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Hunan Evidence-based Medicine Center, Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"bibr1-10760296241268432","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1311-6"},{"key":"bibr2-10760296241268432","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14145"},{"key":"bibr3-10760296241268432","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11195970"},{"key":"bibr4-10760296241268432","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu218"},{"key":"bibr5-10760296241268432","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016784"},{"issue":"7","key":"bibr6-10760296241268432","first-page":"95S","volume":"24","author":"Hawkins 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