{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:38:00Z","timestamp":1782376680245,"version":"3.54.5"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Clinical Medicine Plus X - Young Scholars Project, Peking University, the Fundamental Research Funds for the Central Universities","award":["PKU2022LCXQ031"],"award-info":[{"award-number":["PKU2022LCXQ031"]}]},{"name":"Wu Jieping Medical Foundation Runze Fund for Critical Care Medicine","award":["NO: 320\u00b76750\u00b72022-2-34"],"award-info":[{"award-number":["NO: 320\u00b76750\u00b72022-2-34"]}]},{"DOI":"10.13039\/501100005153","name":"China National Funds for Distinguished Young Scientists","doi-asserted-by":"publisher","award":["Grant NO.: 82202326"],"award-info":[{"award-number":["Grant NO.: 82202326"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>Disseminated intravascular coagulation (DIC) poses a high mortality risk, yet its exact impact remains contentious. This study investigates DIC's association with mortality in individuals with sepsis, emphasizing multiple organ function. Using data from the Peking University People's Hospital Investigation on Sepsis-Induced Coagulopathy database, we categorized patients into DIC and non-DIC groups based on DIC scores within 24\u2005h of ICU admission (&lt; 5 cutoff). ICU mortality was the main outcome. Initial data comparison preceded logistic regression analysis of mortality factors post-propensity score matching (PSM). Employing mediation analysis estimated direct and indirect associations. Of 549 participants, 131 were in the DIC group, with the remaining 418 in the non-DIC group. Following baseline characteristic presentation, PSM was conducted, revealing significantly higher nonplatelet sequential organ failure assessment (nonplt-SOFA) scores (6.3\u2009\u00b1\u20092.7 vs 5.0\u2009\u00b1\u20092.5, P\u2009&lt;\u20090.001) and in-hospital mortality rates (47.3% vs 29.5%, P\u2009=\u20090.003) in the DIC group. A significant correlation between DIC and in-hospital mortality persisted (OR 2.15, 95% CI 1.29\u20133.59, P\u2009=\u20090.003), with nonplt-SOFA scores (OR 1.16, 95% CI 1.05-1.28, P\u2009=\u20090.004) and hemorrhage (OR 2.33, 95% CI 1.08-5.03, P\u2009=\u20090.032) as predictors. The overall effect size was 0.1786 (95% CI 0.0542-0.2886), comprising a direct effect size of 0.1423 (95% CI 0.0153-0.2551) and an indirect effect size of 0.0363 (95% CI 0.0034-0.0739), with approximately 20.3% of effects mediated. These findings underscore DIC's association with increased mortality risk in patients with sepsis, urging anticoagulation focus over bleeding management, with organ dysfunction assessment recommended for anticoagulant treatment efficacy.<\/jats:p>","DOI":"10.1177\/10760296241271358","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T09:45:03Z","timestamp":1723023903000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Exploring the Mediating Role of Multiple Organ Dysfunction in Sepsis-Induced Disseminated Intravascular Coagulation and Its Impact on Worsening Prognosis"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7620-3232","authenticated-orcid":false,"given":"Guangjie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxiao","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Peking University People's Hospital, Beijing 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongtao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department Critical Care Medicine, The Second People's Hospital of Chengyang District, Qingdao 266111, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youzhong","family":"An","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"bibr1-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"bibr2-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.5804"},{"key":"bibr3-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30322-5"},{"key":"bibr4-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1605-5"},{"key":"bibr5-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.01.010"},{"key":"bibr6-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-019-0198-4"},{"key":"bibr7-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1186\/cc5074"},{"key":"bibr8-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-023-06980-6"},{"key":"bibr9-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12537"},{"key":"bibr10-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.36"},{"key":"bibr11-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13911"},{"key":"bibr12-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.37"},{"key":"bibr13-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.10.013"},{"key":"bibr14-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1616068"},{"key":"bibr15-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.14.1754"},{"key":"bibr16-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"bibr17-10760296241271358","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.11.11"},{"key":"bibr18-10760296241271358","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1254046"},{"key":"bibr19-10760296241271358","author":"Semeraro 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