{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:27:41Z","timestamp":1787621261971,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Key R&D Projects of Guangzhou Science and Technology Program","award":["2023B03J1243"],"award-info":[{"award-number":["2023B03J1243"]}]},{"name":"the Science Foundation of the Fujian Province","award":["2022J11454"],"award-info":[{"award-number":["2022J11454"]}]},{"name":"Sanming City Science and Technology Joint Funding Project","award":["2023-S-110"],"award-info":[{"award-number":["2023-S-110"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013289"],"award-info":[{"award-number":["2024A1515013289"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute venous thromboembolism (VTE) in children presents unique challenges due to the limitations of standard anticoagulation therapies. Herein, we aimed to systematically review randomized controlled trials (RCTs) evaluating the efficacy and safety of direct oral anticoagulants (DOACs) in pediatric patients with acute VTE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed and Embase databases were searched for RCTs comparing DOACs to standard anticoagulation in pediatric VTE patients. Efficacy outcomes included VTE recurrence and all-cause mortality, while safety outcomes comprised major bleeding and other adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three RCTs with 790 participants were included. When compared with standard anticoagulation, DOACs demonstrated a reduced risk of VTE recurrence (risk difference[RD]\u2009=\u2009\u22123%, 95% confidence interval[CI]: \u22126% to 0%, P\u2009=\u20090.04) and an increased risk of any adverse event (RD\u2009=\u20098%, 95% CI: 1% to 14%, P\u2009=\u20090.02). No significant differences were found in all-cause mortality, major bleeding, clinically relevant non-major bleeding, or total bleeding between the DOAC and control groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DOACs, primarily dabigatran and rivaroxaban, are non-inferior to standard anticoagulants in reducing VTE recurrence in pediatric patients, with comparable safety profiles. Further research is essential to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296241271386","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T15:16:25Z","timestamp":1722957385000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Direct Oral Anticoagulants for Treating Acute Venous Thromboembolism in Children: Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.1177","volume":"30","author":[{"given":"Xin","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sanming First Affiliated Hospital of Fujian Medical University, SanMing, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1280-0158","authenticated-orcid":false,"given":"Wengen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"},{"name":"NHC Key Laboratory of Assisted Circulation and Vascular Diseases (Sun Yat-sen University), Guangzhou, China"},{"name":"National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renrong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sanming First Affiliated Hospital of Fujian Medical University, SanMing, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"bibr1-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.5.1251.1251"},{"key":"bibr2-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1616947"},{"key":"bibr3-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1598004"},{"key":"bibr4-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.058159"},{"key":"bibr5-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310907"},{"key":"bibr6-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107039"},{"key":"bibr7-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"bibr8-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"bibr9-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21740"},{"key":"bibr10-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031007"},{"key":"bibr11-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz405"},{"key":"bibr12-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.09.025"},{"key":"bibr13-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxac387"},{"key":"bibr14-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30368-9"},{"key":"bibr15-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30219-4"},{"key":"bibr16-10760296241271386","doi-asserted-by":"publisher","DOI":"10.34172\/PS.2020.42"},{"key":"bibr17-10760296241271386","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"bibr18-10760296241271386","volume":"366","author":"Sterne 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