{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:43:34Z","timestamp":1785242614297,"version":"3.55.0"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Since several studies have examined the use of direct oral anticoagulants (DOACs) in treating patients with splanchnic vein thrombosis (SVT), we conducted a meta-analyses to assess the safety and efficacy of DOACs compared to vitamin K antagonists (VKAs) in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a comprehensive search using the PubMed, Embase, and Cochrane Library databases until June 2024. We used odds ratios (ORs) and 95% confidence intervals (CIs) as the effect measures to compare DOACs with VKAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 9 observational studies were included. The pooled analysis revealed that a trend towards higher complete recanalization rates with DOACs (71.4%) compared to VKAs (55.3%), though not statistically significant (OR 1.95; 95%CI 0.70 to 5.44). For SVT extension, a significant effect was observed favoring DOACs (OR 0.12; 95%CI 0.03 to 0.54). No significant differences were found in other efficacy outcomes or safety outcomes, except for major bleeding, which was significantly lower with DOACs (OR 0.27; 95%CI 0.13 to 0.56).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DOACs are superior to VKAs in SVT extension and major bleeding, suggesting that DOACs may be a favorable treatment option in the treatment of SVT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296241274750","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T02:46:05Z","timestamp":1723517165000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Direct Oral Anticoagulants in Patients with Splanchnic Vein Thrombosis: A Systematic Reviews and Meta-Analysis"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5824-4952","authenticated-orcid":false,"given":"Yun","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Ganzhou People's Hospital, Ganzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meimei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Nephrology, the First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"bibr1-10760296241274750","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S197732"},{"key":"bibr2-10760296241274750","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100667"},{"key":"bibr3-10760296241274750","author":"Custo S","year":"2024","journal-title":"Hamostaseologie"},{"key":"bibr4-10760296241274750","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9123916"},{"key":"bibr5-10760296241274750","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz405"},{"key":"bibr6-10760296241274750","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001193"},{"key":"bibr7-10760296241274750","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"bibr8-10760296241274750","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"bibr9-10760296241274750","unstructured":"Wells GA, Shea B, O'Connell D, et al. 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