{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:10:42Z","timestamp":1788487842269,"version":"build-2803163510"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Henan Provincial Science and Technology Key Research and Development Project","award":["222102310667"],"award-info":[{"award-number":["222102310667"]}]},{"name":"Zhengzhou Science and Technology Benefit People Project","award":["2022KJHM0033"],"award-info":[{"award-number":["2022KJHM0033"]}]},{"name":"Zhengzhou Second-tier Famous Doctor Support Special Project in 2021"},{"name":"Henan Key Laboratory of Cardiac Remodeling and Transplantation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Elevated circulating D-dimer levels have been shown to be a predictor of in-hospital mortality in a variety of diseases; however, the relationship between D-dimer and the in-hospital prognosis of non-ST-segment elevation myocardial infarction (NSTEMI) remains unclear. This retrospective study included 662 non-diabetic patients with NSTEMI. Independent risk factors were identified by multivariate analyses, and the receiver operating characteristic (ROC) curve analyses were performed to compare the predictive value of D-dimer, albumin (ALB), and D-dimer to albumin ratio (DAR) for in-hospital death in NSTEMI. Logistic regression model with restricted cubic spline (RCS) was used to further explore the linear or nonlinear relationship between D-dimer and the risk of death. In-hospital mortality occurred in 38 (5.7%) patients. Multivariate analysis showed that D-dimer (per increase of 500 ng) was identified as an independent predictor for in-hospital mortality in non-diabetic patients with NSTEMI (OR\u2009=\u20091.19, 95% CI: 1.03\u20131.40, P\u2009=\u20090.036). D-dimer demonstrated good predictive performance for in-hospital mortality with an area under the ROC curve (AUC) value of 0.75 (95% CI: 0.66\u20130.83), and there was no significant difference in the predictive ability of D-dimer, ALB (AUC\u2009=\u20090.70, 95% CI: 0.61\u20130.79) and DAR (AUC\u2009=\u20090.75, 95% CI: 0.66\u20130.84). In addition, RCS analysis showed a linear relationship between D-dimer and the risk of in-hospital mortality (P for nonlinear\u2009=\u20090.747). D-dimer can be used as a simple, reliable and valuable biomarker for predicting in-hospital mortality in non-diabetic patients with NSTEMI and is linearly associated with the risk of death.<\/jats:p>","DOI":"10.1177\/10760296241276820","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T02:52:37Z","timestamp":1724295157000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictive Value of D-Dimer for In-Hospital Mortality in Non-Diabetic Patients with Non-ST-segment Elevation Myocardial Infarction"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1150-4826","authenticated-orcid":false,"given":"Bin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Seventh People's Hospital of Zhengzhou & Henan Key Laboratory of Cardiac Remodeling and Transplantation, Zhengzhou, China"},{"name":"College of Medicine, Xinxiang Medical University, Xinxiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Rehabilitation, The Seventh People's Hospital of Zhengzhou, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiac Rehabilitation, The Seventh People's Hospital of Zhengzhou, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7151-4293","authenticated-orcid":false,"given":"Wensen","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and Special Medical Treatment, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Seventh People's Hospital of Zhengzhou & Henan Key Laboratory of Cardiac Remodeling and Transplantation, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"bibr1-10760296241276820","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908610"},{"issue":"9","key":"bibr2-10760296241276820","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1007\/s00392-020-01612-1","volume":"109","author":"Neumann JT","year":"2020","journal-title":"Clin Res Cardiol: Off J Ger Cardiac 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