{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:07:26Z","timestamp":1788872846893,"version":"build-2803163510"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences","award":["NCRC2020013"],"award-info":[{"award-number":["NCRC2020013"]}]},{"name":"the National High Level Hospital Clinical Research Funding","award":["2023-GSP-GG-40"],"award-info":[{"award-number":["2023-GSP-GG-40"]}]},{"name":"the CAMS Innovation Fund for Medical Sciences","award":["2023-I2M-1-002"],"award-info":[{"award-number":["2023-I2M-1-002"]}]},{"name":"the CS Optimizing Antithrombotic Research Fund","award":["BJUHFCSOARF201801-06"],"award-info":[{"award-number":["BJUHFCSOARF201801-06"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recently, the effect of Lipoprotein(a) [Lp(a)] on thrombogenesis has aroused great interest, while inflammation has been reported to modify the Lp(a)-associated risks through an unidentified mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate the association between platelet reactivity with Lp(a) and high-sensitivity C-reactive protein (hs-CRP) levels in percutaneous intervention (PCI) patients treated with clopidogrel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were collected from 10,724 consecutive PCI patients throughout the year 2013 in Fuwai Hospital. High on-treatment platelet reactivity (HTPR) and low on-treatment platelet reactivity (LTPR) were defined as thrombelastography (TEG) maximum amplitude of adenosine diphosphate-induced platelet (MA\n                      <jats:sub>ADP<\/jats:sub>\n                      )\u2009&gt;\u200947 mm and\u2009&lt;\u200931 mm, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>6615 patients with TEG results were finally enrolled. The mean age was 58.24\u2009\u00b1\u200910.28 years and 5131 (77.6%) were male. Multivariable logistic regression showed that taking Lp(a)\u2009&lt;\u200930 mg\/dL and hs-CRP\u2009&lt;\u20092 mg\/L as the reference, isolated Lp(a) elevation [Lp(a)\u2009\u2265\u200930 mg\/dL and hs-CRP\u2009&lt;\u20092 mg\/L] was not significantly associated with HTPR ( P\u2009=\u20090.153) or LTPR ( P\u2009=\u20090.312). However, the joint elevation of Lp(a) and hs-CRP [Lp(a)\u2009\u2265\u200930 mg\/dL and hs-CRP\u2009\u2265\u20092 mg\/L] exhibited enhanced association with both HTPR (OR:1.976, 95% CI 1.677\u20132.329) and LTPR (OR:0.533, 95% CI 0.454\u20130.627).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The isolated elevation of Lp(a) level was not an independent indicator for platelet reactivity, yet the concomitant elevation of Lp(a) and hs-CRP levels was significantly associated with increased platelet reactivity. Whether intensified antiplatelet therapy or anti-inflammatory strategies could mitigate the risks in patients presenting combined Lp(a) and hs-CRP elevation requires future investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296241280711","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T09:04:17Z","timestamp":1725959057000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Elevated High-Sensitivity C-Reactive Protein Level Enhances the Impact of Lipoprotein(a) on Platelet Reactivity in PCI Patients Treated with Clopidogrel"],"prefix":"10.1177","volume":"30","author":[{"given":"Kexin","family":"Zhang","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical 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